Multidisciplinary Department of Medico-Surgical and Dentistry Specialties, "Luigi Vanvitelli" University of Campania, Naples, Italy.
Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Campobasso, Italy.
J Orthop Traumatol. 2022 Feb 5;23(1):7. doi: 10.1186/s10195-022-00628-9.
This study aimed to report the clinical and functional results of a series of patients with isolated primary patellofemoral osteoarthritis (PFOA) treated with intraarticular injection of microfragmented autologous adipose tissue plus knee arthroscopy. The results were also analyzed in relation to the age and body mas index (BMI) of patients, and to the stage of PFOA.
Twenty-three patients with early-to-moderate (stage 1-3 according to the Iwano classification system) PFOA who received this treatment were retrospectively analyzed, with a mean follow-up of 22.1 ± 4.2 months. Patients were assessed using the International Knee Society (IKS) knee and function and visual analog scale (VAS) scores, and relative to their capacity for climbing stairs. Differences in improvements of IKS and VAS scores in relation to age (< 60 versus ≥ 60 years), BMI (< 30 versus ≥ 30 kg/m), and stage of PFOA (stages 1-2 versus stage 3) were finally analyzed.
The mean IKS knee score significantly improved from 35.6 ± 14.9 points preoperatively to 61.9 ± 17.8 points at the latest follow-up, while the mean IKS function score significantly improved from 52.0 ± 14.7 points preoperatively to 82.3 ± 19.1 points at the latest follow-up. The mean VAS score significantly decreased from 8.7 ± 2.2 preoperatively to 5.2 ± 2.5 at the latest follow-up. A significant improvement in the capacity to climb stairs was found. No significant differences in improvements of IKS knee and function and VAS scores were found in relation to age, BMI, or stage of PFOA.
Intraarticular injection of microfragmented autologous adipose tissue following arthroscopic debridement significantly improved overall clinical and functional scores in patients with early or moderate isolated primary PFOA at a mean follow-up of almost 2 years. Improvements were not significantly affected by age, BMI, or stage of PFOA.
Level IV, retrospective case series.
本研究旨在报告一组接受关节内注射微粉碎自体脂肪组织联合膝关节镜治疗的单纯髌股关节炎（PFOA）患者的临床和功能结果。还分析了患者的年龄、体重指数（BMI）以及 PFOA 分期与结果之间的关系。
回顾性分析了 23 例接受这种治疗的早期至中期（根据 Iwano 分类系统为 1-3 期）PFOA 患者，平均随访 22.1±4.2 个月。采用国际膝关节学会（IKS）膝关节和功能评分以及视觉模拟评分（VAS）评估患者，并评估其爬楼梯的能力。最后分析了 IKS 和 VAS 评分的改善与年龄（<60 岁与≥60 岁）、BMI（<30 千克/平方米与≥30 千克/平方米）和 PFOA 分期（1-2 期与 3 期）之间的差异。
平均 IKS 膝关节评分从术前的 35.6±14.9 分显著改善至末次随访时的 61.9±17.8 分，平均 IKS 功能评分从术前的 52.0±14.7 分显著改善至末次随访时的 82.3±19.1 分。平均 VAS 评分从术前的 8.7±2.2 分显著下降至末次随访时的 5.2±2.5 分。爬楼梯的能力也显著提高。IKS 膝关节和功能评分以及 VAS 评分的改善与年龄、BMI 或 PFOA 分期均无显著差异。
关节镜下清创术后关节内注射微粉碎自体脂肪组织可显著改善早期或中期单纯原发性 PFOA 患者的整体临床和功能评分，平均随访近 2 年。改善情况与年龄、BMI 或 PFOA 分期无关。
IV 级，回顾性病例系列研究。
