Thermlanseedlines A-G，来自蓝花棘豆种子的 7 种具有抗病毒和杀虫活性的 Thermopsine 生物碱
Thermlanseedlines A-G, seven thermopsine-based alkaloids with antiviral and insecticidal activities from the seeds of Thermopsis lanceolata R. Br.
机构信息
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
出版信息
Fitoterapia. 2022 Apr;158:105140. doi: 10.1016/j.fitote.2022.105140. Epub 2022 Feb 2.
Seven undescribed thermopsine-based alkaloids (1-7), including one undescribed biogenetically related intermediate (7), were isolated from the seeds of Thermopsis lanceolata R. Br. Compound 1 possessed a 6/6-6 tricyclic skeleton, while compounds 2-6 represented three rare dimerization patterns constructed by quinolizidine alkaloids. Their structures were elucidated by comprehensive spectroscopic data analysis as well as ECD calculations. Biologically, compound 6 displayed significant anti-Tomato spotted wilt virus (TSWV) activity compared with the positive control ningnanmycin. Moreover, compound 1 exhibited good insecticidal activity against Aphis fabae with LC value of 25.2 mg/L.
从苦马豆种子中分离得到 7 个未被描述的基于 Thermopsine 的生物碱（1-7），包括一个未被描述的生物相关中间体（7）。化合物 1 具有 6/6-6 三环骨架，而化合物 2-6 代表了由喹诺里西丁生物碱构建的三种罕见的二聚化模式。通过综合光谱数据分析和 ECD 计算确定了它们的结构。在生物学方面，与阳性对照宁南霉素相比，化合物 6 表现出显著的抗番茄斑萎病毒（TSWV）活性。此外，化合物 1 对菜蚜具有良好的杀虫活性，LC 值为 25.2 mg/L。
Zotero 插件