Li Yi, Guo Chunjing, Chen Qiang, Su Yanguo, Guo Huimin, Liu Ruoyang, Sun Changgang, Mi Shuqi, Wang Jinqiu, Chen Daquan
Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs, School of Pharmacy, Yantai University, Yantai 264005, PR China.
College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China.
Int J Biol Macromol. 2022 Mar 31;202:691-706. doi: 10.1016/j.ijbiomac.2022.01.194. Epub 2022 Feb 3.
Pneumonia can lead to high morbidity and mortality secondary to uncontrolled inflammation of the lung tissue. Blocking cytokine storm storms may be the key to saving the life of patients with severe pneumonia. According to the medicinal guide theory of Traditional Chinese Medicine (TCM) and the inherent affinity with macrophages for the site of inflammation, we constructed the drug delivery platform (MNPs) derived from macrophage-membrane encapsulated reaction oxygen species (ROS)-responsive Platycodon grandiflorum polysaccharides (PGP) nanoparticles (PNPs) to calm the cytokine storm and improve lung inflammation. By loading the anti-inflammatory agent Curcumin (Cur), we demonstrated that MNPs@Cur significantly attenuated inflammation and cytokine storm syndrome in acute lung injury (ALI) mice by suppressing pro-inflammatory factor production and inflammatory cell infiltration. Interestingly, we observed that the PNPs also have potent pulmonary targeting ability compared to other polysaccharide carriers, which is in line with the medicinal guide theory of TCM. Our study revealed the rational design of drug delivery platforms to improve the treatment of lung injury, which inherits and develops the important theories of TCM through the perfect combination of guide theory and biomimetic nanotechnology and provides the experimental scientific basis for the clinical application of channel ushering drugs.
肺炎可导致继发于肺组织炎症失控的高发病率和死亡率。阻断细胞因子风暴可能是挽救重症肺炎患者生命的关键。根据中医的引经报使理论以及炎症部位与巨噬细胞的内在亲和力，我们构建了源自巨噬细胞膜包裹的活性氧（ROS）响应型桔梗多糖（PGP）纳米颗粒（PNP）的药物递送平台（MNP），以平息细胞因子风暴并改善肺部炎症。通过负载抗炎剂姜黄素（Cur），我们证明MNP@Cur通过抑制促炎因子产生和炎症细胞浸润，显著减轻了急性肺损伤（ALI）小鼠的炎症和细胞因子风暴综合征。有趣的是，我们观察到与其他多糖载体相比，PNP也具有强大的肺部靶向能力，这与中医的引经报使理论相符。我们的研究揭示了药物递送平台的合理设计以改善肺损伤的治疗，通过引经报使理论与仿生纳米技术的完美结合，继承和发展了中医的重要理论，并为通道引经药物的临床应用提供了实验科学依据。
