College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, PR China.
Zhejiang Xinguang Pharmaceutical Limited Liability Company, Shaoxing 312400, PR China.
Fitoterapia. 2022 Apr;158:105142. doi: 10.1016/j.fitote.2022.105142. Epub 2022 Feb 4.
This is the first phytochemical investigation of Schisandra tomentella A. C. Smith. 11 lignans and 8 sesquiterpenoids, were isolated from the stems of S. tomentella, including two undescribed lignans, tomentaschinins A-B (1-2), and two new sesquiterpenoids, tomentaschinnes A-B (3-4). Their structures were elucidated based on the interpretation of their spectroscopic data. Cytotoxicity and MDR reversal effect of these compounds were screened on multidrug resistance cancer cell line MCF-7/ADR, and results showed gomisin M (7) could promote the efficacy of adriamycin against MCF-7/ADR.
这是对五味子属毛五味子的首次植物化学研究。从毛五味子的茎中分离得到了 11 种木脂素和 8 种倍半萜，包括两种未描述的木脂素，毛五味子素 A-B（1-2），和两种新的倍半萜，毛五味子素 A-B（3-4）。根据光谱数据的解释，确定了它们的结构。对这些化合物的细胞毒性和多药耐药性逆转作用进行了筛选，结果表明戈米辛 M（7）可增强阿霉素对 MCF-7/ADR 的疗效。
