从五味子果实中分离得到的一个新的三萜、一个倍半萜和具有保肝作用的木脂素。
A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China.
Institute of Medical Information & Library, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 3 Yabao Street, Beijing 100020, China.
出版信息
Molecules. 2017 Nov 10;22(11):1931. doi: 10.3390/molecules22111931.
A new nortriterpenoid, 19()-hydroxyl-wuweizidilactone H (), and a sesquiterpene, (6)--chamigrenic acid (), together with one known nortriterpenoid, wuweizidilactone H (), and three known hepatoprotective lignans, micrantherin A (), gomisin M₂ () and schizandrin () were isolated from the fruit of . Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the absolute configuration of was confirmed for the first time. In vitro assays, compounds - (10 μM) exhibited hepatoprotective activities (survival rate: 44%, 43% and 44%) against damage induced by -acetyl--aminophenol (APAP) in human liver carcinoma (HepG2) cells.
从五味子果实中分离得到了一个新的三萜类化合物 19()-羟基五味子醇 H ()和一个倍半萜类化合物 (6)--恰米格雷宁酸 ()，以及一个已知的三萜类化合物五味子醇 H ()和三个已知的保肝木脂素化合物，即密枝五味子 A ()、戈米辛 M₂ ()和五味子丙素 ()。通过 UV、IR、HRESIMS、NMR 谱和 X 射线分析确定了它们的结构。其中，首次确定了的绝对构型。体外实验结果表明，化合物 - (10 μM)对 -乙酰--氨基酚 (APAP)诱导的人肝癌 (HepG2)细胞损伤具有保肝活性（存活率：44%、43%和 44%）。
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