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使用 NIPAM 凝胶剂量计和同心摆动机器模拟呼吸过程中的剂量分布:一项可行性研究。

Using NIPAM gel dosimeter and concentric swing machine to simulate the dose distribu- tion during breathing: A feasibility study.

机构信息

Department of Radiation Oncology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.

Department of Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan.

出版信息

Technol Health Care. 2022;30(S1):123-133. doi: 10.3233/THC-228012.

DOI:10.3233/THC-228012
PMID:35124590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9028686/
Abstract

BACKGROUND

Radiotherapy plays an important role in cancer treatment today. Successful radiotherapy includes precise positioning and accurate dosimetry.

OBJECTIVE

To use NIPAM gel dosimeter and concentric swing machine to simulate and evaluate the feasibility of lung or upper abdominal tumor dose distribution during breathing.

METHODS

We used a concentric swing machine to simulate actual radiotherapy for lung or upper abdomen tumors. A 4 × 4 cm2 irradiation field area was set and MRI was performed. Next, readout analysis was performed using MATLAB and the 3 mm, 3% gamma passing rate > 95% was used as a basis for evaluation.

RESULTS

The concentric dynamic dose curve for a simulated respiratory rate of 3 seconds/breath and 4 × 4 cm2 field was compared with 4 × 4, 3 × 3, and 2 × 2 cm2 treatment planning systems (TPS), and the 3 mm, 3% gamma passing rate was 42.87%, 54.96%, and 49.92%, respectively. Pre-simulation showed that the high-dose region dose curve was similar to the 2 × 2 cm2 TPS result. After appropriate selection and comparison, we found that the 3 mm, 3% gamma passing rate was 97.92% on comparing the > 60% dose curve with the 2 × 2 cm2 TPS.

CONCLUSIONS

NIPAM gel dosimeter and concentric swing machine use is feasible to simulate dose distribution during breathing and results conforming to clinical evaluation standards.

摘要

背景

放射治疗在当今癌症治疗中发挥着重要作用。成功的放射治疗包括精确的定位和准确的剂量测量。

目的

使用 NIPAM 凝胶剂量计和同心摆动器模拟和评估呼吸过程中肺部或上腹部肿瘤剂量分布的可行性。

方法

我们使用同心摆动器模拟肺部或上腹部肿瘤的实际放射治疗。设置 4×4 cm2 的照射野区域并进行 MRI 检查。然后,使用 MATLAB 进行读出分析,以 3mm、3%的伽马通过率>95%作为评估依据。

结果

模拟呼吸率为 3 秒/次和 4×4 cm2 场的同心动态剂量曲线与 4×4、3×3 和 2×2 cm2 治疗计划系统(TPS)进行了比较,3mm、3%的伽马通过率分别为 42.87%、54.96%和 49.92%。预模拟显示高剂量区域剂量曲线与 2×2 cm2 TPS 结果相似。经过适当的选择和比较,我们发现比较>60%剂量曲线时,3mm、3%的伽马通过率为 97.92%,与 2×2 cm2 TPS 一致。

结论

NIPAM 凝胶剂量计和同心摆动器的使用可以模拟呼吸过程中的剂量分布,并且结果符合临床评估标准。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/ec3c9362f421/thc-30-thc228012-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/5fdaa065dfd1/thc-30-thc228012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/7a7a35738bd3/thc-30-thc228012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/041be3bb3b55/thc-30-thc228012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/9fb2db3eccf1/thc-30-thc228012-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/41e27a6816d5/thc-30-thc228012-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/ec3c9362f421/thc-30-thc228012-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/5fdaa065dfd1/thc-30-thc228012-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/7a7a35738bd3/thc-30-thc228012-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/041be3bb3b55/thc-30-thc228012-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/9fb2db3eccf1/thc-30-thc228012-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/41e27a6816d5/thc-30-thc228012-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81a6/9028686/ec3c9362f421/thc-30-thc228012-g006.jpg

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本文引用的文献

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PLoS One. 2016 May 18;11(5):e0155797. doi: 10.1371/journal.pone.0155797. eCollection 2016.
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Multiple breath-hold CBCT for online image guided radiotherapy of lung tumors: simulation with a dynamic phantom and first patient data.多呼吸暂停 CBCT 用于肺肿瘤在线图像引导放疗:动态体模模拟和首例患者数据。
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