吲哚美辛和丙谷美辛对大鼠胃黏膜体外释放6-氧代前列环素F1α的比较作用。
Comparative effects of indomethacin and proglumetacin on 6-oxo-PGF1 alpha released ex vivo by rat gastric mucosa.
作者信息
Conti P, Alesse E, Cifone M G
出版信息
Int J Tissue React. 1986;8(1):31-4.
PMID:3512465
Abstract
The authors compare the effect of indomethacin and proglumetacin on the production of prostacyclin in the rat gastric mucosa, and investigate the potential ulcerogenic effect elicited by the two drugs. The results show that indomethacin and proglumetacin, at doses giving similar inhibition of gastric-protacyclin synthesis, drastically differ in their gastric ulcerogenic effects.
摘要
作者比较了吲哚美辛和丙谷美辛对大鼠胃黏膜前列环素生成的影响，并研究了这两种药物引发胃溃疡的潜在作用。结果表明，吲哚美辛和丙谷美辛在给予相似程度抑制胃前列环素合成的剂量时，它们的胃溃疡形成作用存在显著差异。
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