Davis Anna, Khachemoune Amor
Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
Department of Dermatology, State University of New York Downstate, Brooklyn, NY, USA.
Arch Dermatol Res. 2023 Jan;315(1):7-16. doi: 10.1007/s00403-022-02323-5. Epub 2022 Feb 6.
Primary cutaneous cribriform apocrine carcinoma (PCCAC) is an exceedingly rare sweat gland carcinoma. Clinically, it most often presents as a singular, asymptomatic nodule or cyst on the extremities of middle-aged patients and follows an indolent course. Both visceral and cutaneous cribriform tumors exist in nature. While a cribriform pattern is well recognized in tumors of visceral organs, there is a paucity in the literature on the defining characteristics for primary cutaneous tumors. Consensus regarding diagnostic criteria, etiology, and management protocols has yet to be achieved. We conducted an extensive literature review using pre-determined search criteria, resulting in 12 identified case reports and series on PCCAC that were subsequently analyzed. All data were compiled to provide a comprehensive update on the existing information regarding clinical presentation, histopathology, and management of reported PCCACs, as well as differential diagnosis, controversial issues, and recommendations for future considerations.
原发性皮肤筛状大汗腺癌（PCCAC）是一种极其罕见的汗腺癌。临床上，它最常表现为中年患者四肢的单个无症状结节或囊肿，病程进展缓慢。内脏和皮肤筛状肿瘤在自然界中均存在。虽然筛状模式在内脏器官肿瘤中已得到充分认识，但关于原发性皮肤肿瘤的定义特征的文献却很少。关于诊断标准、病因和治疗方案尚未达成共识。我们使用预先确定的搜索标准进行了广泛的文献综述，结果确定了12篇关于PCCAC的病例报告和系列研究，并随后进行了分析。汇总所有数据，以全面更新有关已报道的PCCAC的临床表现、组织病理学和治疗的现有信息，以及鉴别诊断、争议问题和未来考虑的建议。
