Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, 610041, PR China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, 610041, PR China.
Reprod Biol Endocrinol. 2020 Aug 11;18(1):81. doi: 10.1186/s12958-020-00634-8.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-aged women. It is reported that intrauterine exposure to hyperandrogenism may induce the development of PCOS and associated complications in later life. To analyze the intrauterine androgen levels in infants born to PCOS mothers, we evaluated the androgen levels in fetal cord blood through a meta-analysis of observational studies.
The following online databases were systematically searched: PubMed, EMBASE, Cochrane library databases and Web of Science up to December 2019. Human studies compared cord blood androgen levels, including testosterone (T) and androstenedione (ADION), in fetal cord blood of mothers with and without PCOS. Statistical analysis was performed in Review Manager, Version 5.3, with the inverse variance method based on a random-effects model.
A total of 7 articles were scrutinized and a total of 570 samples including 268 female and 222 male infants were qualified for review. In the mass spectrograph (MS) subgroup, PCOS mothers showed no signs of increased T concentration in umbilical cord blood at birth (4 studies; hazard ratio [HR] = - 0.05; 95% confidence interval [CI] = [- 0.33,0.24]; I = 7%; P = 0.75; fixed-effects model). ADION level tends to be lower in daughters' cord blood of PCOS mothers (3 studies; HR = -0.59; 95%CI = [- 1.00, - 0.19]; I = 0%; P = 0.004; fixed-effects model).
Fetal cord blood T level is not related to PCOS, while ADION levels tend to be lower in the cord blood of daughters born to mothers with PCOS.
多囊卵巢综合征(PCOS)是育龄妇女最常见的内分泌疾病之一。据报道,子宫内暴露于高雄激素血症可能会导致 PCOS 的发展以及以后生活中的相关并发症。为了分析患有 PCOS 的母亲所生婴儿的子宫内雄激素水平,我们通过对观察性研究的荟萃分析评估了胎儿脐带血中的雄激素水平。
系统检索了以下在线数据库:PubMed、EMBASE、Cochrane 图书馆数据库和 Web of Science,检索时间截至 2019 年 12 月。这些研究比较了患有和不患有 PCOS 的母亲的胎儿脐带血中的雄激素水平,包括睾酮(T)和雄烯二酮(ADION)。采用 Review Manager 软件,基于随机效应模型的逆方差法进行统计分析。
共筛选出 7 篇文章,共有 570 例样本符合纳入标准,其中包括 268 例女性和 222 例男性婴儿。在质谱(MS)亚组中,患有 PCOS 的母亲在出生时其脐带血中的 T 浓度并没有增加的迹象(4 项研究;风险比[HR] = - 0.05;95%置信区间[CI] = [- 0.33,0.24];I²= 7%;P = 0.75;固定效应模型)。患有 PCOS 的母亲的女儿的脐带血中的 ADION 水平往往较低(3 项研究;HR = -0.59;95%CI = [- 1.00, - 0.19];I²= 0%;P = 0.004;固定效应模型)。
胎儿脐带血 T 水平与 PCOS 无关,而患有 PCOS 的母亲所生女儿的脐带血中的 ADION 水平往往较低。