在印度南部一家三级护理糖尿病中心，报告的 2 型糖尿病患者口腔癌的频率和关联 - 一项回顾性研究。

Frequency and association of self-reported oral cancer among individuals with type 2 diabetes at a tertiary care diabetes centre in South India - A retrospective study.

机构信息

Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital, Chennai, India; School of Health and Social Development, Deakin University, Geelong, Victoria, Australia; Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Chennai, India.

School of Health Sciences, Swinburne University of Technology, Melbourne, Australia.

出版信息

J Diabetes Complications. 2022 Mar;36(3):108129. doi: 10.1016/j.jdiacomp.2022.108129. Epub 2022 Jan 14.

DOI:10.1016/j.jdiacomp.2022.108129

PMID:35125271

Abstract

AIM

To assess the frequency of self-reported oral cancer and associated factors among individuals with type 2 diabetes (T2D) at a tertiary care diabetes centre in South India.

METHODS

Individuals with T2D who reported that they had oral cancer were included from the Diabetes Electronic Medical Records (DEMR) database. To assess the association of oral cancer with T2D, a retrospective nested case-control study design was adopted. Individuals with T2D and oral cancer diagnosed after the diagnosis of T2D (n = 78) were considered 'cases', while T2D without oral cancer were considered 'controls' (312) [in a ratio of 1:4 for cases and controls]. The cases and controls were matched for age, gender and duration of diabetes. Logistic regression was used to model predictors of oral cancer in T2D patients.

RESULTS

Oral cancer was reported in 78 out of 379,138 (0.02%) individuals with T2D registered at the centre. Logistic regression analysis showed that a HbA1c value ≥ 9% had a significant association with oral cancer with an odds ratio of 2.3 (95% CI: 1.2-4.6) after adjusting for confounding factors. Among individuals with T2D, higher frequency of oral cancer prevalence and risk was observed among those who used any form of tobacco (32.6%, OR = 2.52, 95% CI: 1.5-4.3), consumed alcohol (29.2%, OR = 2.01, 95% CI: 1.2-3.3), and those with hypertension (23.9%, OR = 2.05, 95% CI: 1.2-3.6) and hypertriglyceridemia (24.7%, OR = 1.66, 95% CI: 1.01-2.7). Significant independent predictors of oral cancer among T2D were tobacco use (OR = 2.06, 95% CI: 1.1-4.00), high HbA1c (OR = 1.3, 95% CI: 1.03-1.5), hypertension (OR = 2.3, 95% CI: 1.3-4.2) and insulin use (OR = 1.8, 95% CI: 1.03-3.2).

CONCLUSIONS

Regular dental check-ups as part of the follow-up for individuals with T2D will identify and diagnose oral cancer earlier. Further research is required to assess the physiological and biological mechanisms leading to oral cancer in individuals with T2D.

摘要

目的

在印度南部的一家三级保健糖尿病中心评估报告 2 型糖尿病（T2D）个体中自我报告的口腔癌及其相关因素的频率。

方法

从糖尿病电子病历（DEMR）数据库中纳入报告患有口腔癌的 T2D 个体。为了评估口腔癌与 T2D 的相关性，采用回顾性嵌套病例对照研究设计。在 T2D 诊断后诊断出患有口腔癌的 T2D 个体（n=78）被视为“病例”，而无口腔癌的 T2D 个体则被视为“对照”（312 人）[病例与对照的比例为 1:4]。病例和对照按年龄、性别和糖尿病病程进行匹配。使用逻辑回归对 T2D 患者的口腔癌预测因素进行建模。

结果

在该中心登记的 379138 名 T2D 个体中，有 78 人报告患有口腔癌（0.02%）。逻辑回归分析表明，糖化血红蛋白（HbA1c）值≥9%与口腔癌显著相关，调整混杂因素后，比值比（OR）为 2.3（95%置信区间[CI]：1.2-4.6）。在 T2D 个体中，使用任何形式的烟草（32.6%，OR=2.52，95%CI：1.5-4.3）、饮酒（29.2%，OR=2.01，95%CI：1.2-3.3）、高血压（23.9%，OR=2.05，95%CI：1.2-3.6）和高甘油三酯血症（24.7%，OR=1.66，95%CI：1.01-2.7）的个体中，口腔癌的患病率和风险更高。T2D 中口腔癌的显著独立预测因素是烟草使用（OR=2.06，95%CI：1.1-4.00）、高 HbA1c（OR=1.3，95%CI：1.03-1.5）、高血压（OR=2.3，95%CI：1.3-4.2）和胰岛素使用（OR=1.8，95%CI：1.03-3.2）。