Kuang Liangfeng, Gao Weijia, Long Zhiliang, Cao Weifang, Cui Dong, Guo Yongxin, Jiao Qing, Qiu Jianfeng, Su Linyan, Lu Guangming
Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China.
Department of Child Psychology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Psychiatry. 2022 Jan 21;12:750798. doi: 10.3389/fpsyt.2021.750798. eCollection 2021.
By calculating cortical thickness (CT) and cortical structural covariance (SC), we aimed to investigate cortical morphology and cortical inter-regional correlation alterations in adolescent bipolar disorder type I (BD-I) and type II (BD-II) patients.
T1-weighted images from 36 BD-I and 22 BD-II patients and 19 healthy controls (HCs) were processed to estimate CT. CT values of the whole brain were compared among three groups. Cortical regions showing CT differences in groups were regarded as seeds for analyzing cortical SC differences between groups. The relationship between CT and clinical indices was further assessed.
Both BD groups showed cortical thinning in several frontal and temporal areas vs. HCs, and CT showed no significant difference between two BD subtypes. Compared to HCs, both BD groups exhibited reduced SC connections between left superior frontal gyrus (SFG) and right postcentral gyrus (PCG), left superior temporal gyrus (STG) and right pars opercularis, and left STG and right PCG. Compared with HCs, decreased SC connections between left STG and right inferior parietal gyrus (IPG) and right pars opercularis and right STG were only observed in the BD-I group, and left PCG and left SFG only in the BD-II group. CT of right middle temporal gyrus was negatively correlated with number of episodes in BD-II patients.
Adolescent BD-I and BD-II showed commonly decreased CT while presenting commonly and distinctly declined SC connections. This study provides a better understanding of cortical morphology and cortical inter-regional correlation alterations in BD and crucial insights into neuroanatomical mechanisms and pathophysiology of different BD subtypes.
通过计算皮质厚度（CT）和皮质结构协方差（SC），我们旨在研究青少年I型双相情感障碍（BD-I）和II型双相情感障碍（BD-II）患者的皮质形态和皮质区域间相关性改变。
对36例BD-I患者、22例BD-II患者及19名健康对照（HC）的T1加权图像进行处理以估计CT。比较三组全脑的CT值。将组间显示CT差异的皮质区域视为种子区域，用于分析组间皮质SC差异。进一步评估CT与临床指标之间的关系。
与HC相比，两个BD组在多个额叶和颞叶区域均表现出皮质变薄，且CT在两种BD亚型之间无显著差异。与HC相比，两个BD组在左侧额上回（SFG）与右侧中央后回（PCG）、左侧颞上回（STG）与右侧岛盖部、左侧STG与右侧PCG之间的SC连接均减少。与HC相比，仅在BD-I组中观察到左侧STG与右侧顶下小叶（IPG）以及右侧岛盖部与右侧STG之间的SC连接减少，仅在BD-II组中观察到左侧PCG与左侧SFG之间的SC连接减少。BD-II患者右侧颞中回的CT与发作次数呈负相关。
青少年BD-I和BD-II普遍表现出CT降低，同时SC连接普遍且明显减少。本研究有助于更好地理解双相情感障碍中的皮质形态和皮质区域间相关性改变，并为不同BD亚型的神经解剖学机制和病理生理学提供重要见解。
