Sun Hui-Miao, Li Qian-Yun, Xiao Ru-Yi, Zhang Ze-Dong, Yang Xiao-Yan, Yang Jie, Jin Bo, Wen Jia-Xiang, Wu Yan-Jun, Yang Hong, Wang Fan
Department of Magnetic Resonance Imaging (MRI), Children Hospital of Shanxi Province (Shanxi Maternal and Child Health Hospital), Taiyuan, China.
College of Medical Imaging, Shanxi Medical University, Taiyuan, China.
Front Neurol. 2022 Aug 18;13:952405. doi: 10.3389/fneur.2022.952405. eCollection 2022.
To use structural magnetic resonance imaging (3D-MRI) to evaluate the abnormal development of the cerebral cortex in infants with global developmental delay (GDD).
The GDD group includes 67 infants aged between 112 and 699 days with global developmental delay and who underwent T1-weighted MRI scans in Shanxi Children's Hospital from December 2019 to March 2022. The healthy control (HC) group includes 135 normal developing infants aged between 88 and 725 days in Shanxi Children's Hospital from September 2020 to August 2021. Whole-brain T1-weighted MRI scans were carried out with a 3.0-T magnetic resonance scanner, which was later processed using InfantSurfer to perform MR image processing and cortical surface reconstruction. Two morphological features of the cortical surface of the 68 brain regions were computed, i.e., the cortical thickness (CT) and cortical surface area (SA), and compared between the GDD and HC groups.
With regard to the CT, the HC group showed a rapid decrease at first and then a slow increase after birth, and the CT of the GDD group decreased slowly and then became relatively stable. The GDD group showed bilaterally higher hemispherical average CT than those in the HC group. In detail, for the left hemisphere, except in the entorhinal and temporal poles in which the average CT values of the two brain regions were lower than those of the HC group, the CT of the 26 brain regions in the GDD group was higher than those of the HC group ( < 0.05). For the right hemisphere, the CT of the entorhinal in the GDD group was lower than that in the HC group. Otherwise, the CT of the remaining 28 brain regions was higher than those in the HC group ( < 0.05). With regard to the SA, both groups showed a rapid increase after birth till 23 months and remained quite stable afterward. The GDD group shows lower SA bilaterally than that in the HC group. In detail, SA in the GDD group was lower in most cortical regions of both hemispheres than in the HC group ( < 0.05), except for the right temporal pole and entorhinal. When testing for brain asymmetry, we found that the HC group showed obvious asymmetry of CT and SA, while only a few cortical regions in the GDD group showed asymmetry.
运用结构磁共振成像（3D-MRI）评估全球发育迟缓（GDD）婴儿大脑皮层的异常发育情况。
GDD组包括67例年龄在112至699天之间、患有全球发育迟缓且于2019年12月至2022年3月在山西儿童医院接受T1加权MRI扫描的婴儿。健康对照组（HC）包括135例年龄在88至725天之间、于2020年9月至2021年8月在山西儿童医院正常发育的婴儿。使用3.0-T磁共振扫描仪进行全脑T1加权MRI扫描，随后使用InfantSurfer进行处理以进行MR图像处理和皮质表面重建。计算68个脑区皮质表面的两个形态学特征，即皮质厚度（CT）和皮质表面积（SA），并在GDD组和HC组之间进行比较。
关于CT，HC组出生后先快速下降，然后缓慢上升，而GDD组的CT则缓慢下降，然后相对稳定。GDD组双侧半球平均CT高于HC组。具体而言，对于左半球，除内嗅区和颞极这两个脑区的平均CT值低于HC组外，GDD组26个脑区的CT高于HC组（<0.05）。对于右半球，GDD组内嗅区的CT低于HC组。否则，其余28个脑区的CT高于HC组（<0.05）。关于SA，两组在出生后至23个月均快速增加，之后保持相当稳定。GDD组双侧SA低于HC组。具体而言，除右颞极和内嗅区外，GDD组双侧大多数皮质区域的SA低于HC组（<0.05）。在测试脑不对称性时，我们发现HC组显示出明显的CT和SA不对称，而GDD组只有少数皮质区域显示出不对称。
