光照周期和褪黑素给药对大鼠下丘脑视上核神经元形态组织化学改变的影响。
Morphohistochemical alterations of neurons of the supraoptic nucleus of the rat hypothalamus at different durations of the photoperiod and melatonin administration.
机构信息
Department of Medical Biology and Genetics, Bukovinian State Medical University, Chernivtsi, Ukraine.
Department of Obstetrics and Gynecology, Bukovinian State Medical University, Chernivtsi, Ukraine.
出版信息
J Med Life. 2021 Nov-Dec;14(6):810-815. doi: 10.25122/jml-2021-0220.
We studied the morphologic and histochemical organization of neurons of the hypothalamic supraoptic nucleus in rats exposed to different durations of photoperiod and injection of melatonin. Morphometric and histochemical analyses of neurons were performed after staining brain histological sections for RNA. Prolonged illumination leads to more pronounced changes in the parameters of hypothalamic structures at 2 a.m. than at 2 p.m., particularly decreasing the concentration of RNA in the cell nuclei. The use of exogenous melatonin does not normalize the revealed changes in the parameters of the studied structures of the neurons of the supraoptic nucleus of the hypothalamus caused by the prolonged stay of rats under conditions of constant illumination.
我们研究了暴露于不同持续时间的光周期和褪黑素注射的大鼠下丘脑视上核神经元的形态和组织化学组织。在对大脑组织切片进行 RNA 染色后，对神经元进行了形态计量学和组织化学分析。长时间光照导致大鼠在凌晨 2 点的下丘脑结构参数发生更明显的变化，而不是在下午 2 点，特别是细胞核中 RNA 浓度降低。使用外源性褪黑素不能使由于大鼠在持续光照条件下长时间停留而导致的视上核神经元的研究结构的参数的所揭示的变化正常化。
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