Ekimova I V
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, 44 Moris Torez Prospekt, 194223 St. Petersburg, Russia.
Neurosci Behav Physiol. 2003 Jun;33(5):455-60. doi: 10.1023/a:1023459100213.
Histochemical methods were used to detect differently directed changes in the metabolic activity of neurons in the anterior hypothalamic nuclei in rats during hyperthermia, fever, and hypothermia. Hyperthermia induced by high temperatures was associated with increases in the activities of enzymes involved in energy metabolism, with increases in RNA contents in neurons in the supraoptic, paraventricular, and median preoptic nuclei of the anterior hypothalamus of the rat, which is evidence for increases in metabolic activity in the neurons of these nuclei. Endotoxin-induced fever was accompanied by decreases in the metabolic activity of neurons in the median preoptic nucleus, while activity in neurons of the supraoptic and paraventricular nuclei showed no significant change. The development of hypothermia induced by low temperatures was characterized by decreases in the metabolic activity of neurons in the supraoptic, paraventricular, and median preoptic nuclei of the anterior hypothalamus. It is suggested that the differently directed changes in metabolic activity in the neurons of the anterior hypothalamus in hyperthermia, fever, and hypothermia are associated with their roles in the central mechanisms of thermoregulation (median preoptic nucleus) and neurosecretory processes (supraoptic and paraventricular nuclei).
采用组织化学方法检测大鼠在高热、发热和低温状态下，下丘脑前核神经元代谢活性的不同变化趋势。高温诱导的高热与能量代谢相关酶活性增加有关，大鼠下丘脑前部视上核、室旁核和视前正中核神经元中的RNA含量增加，这证明了这些核团中神经元的代谢活性增强。内毒素诱导的发热伴随着视前正中核神经元代谢活性降低，而视上核和室旁核神经元的活性无显著变化。低温诱导的体温过低的发展特征是下丘脑前部视上核、室旁核和视前正中核神经元的代谢活性降低。提示在高热、发热和低温状态下，下丘脑前核神经元代谢活性的不同变化趋势与其在体温调节中枢机制（视前正中核）和神经分泌过程（视上核和室旁核）中的作用有关。
