Zheng Yu, Li Jie, Chen Kang, Zhang Xiaochun, Sun Huan, Li Shujiao, Zhang Xie, Deng Zhenping, Liang Na, Li Shihong
Department of Radiology, Chengdu Second People's Hospital, Chengdu, China.
Department of Radiology, Huadong Hospital Affiliated With Fudan University, Shanghai, China.
Front Oncol. 2022 Jan 20;11:815967. doi: 10.3389/fonc.2021.815967. eCollection 2021.
To compare conventional diffusion weighted imaging (DWI), intravoxel incoherent motion imaging (IVIM) and diffusion kurtosis imaging (DKI) in differentiating malignant and benign lung lesions.
Fifty-five consecutive patients with lung lesions underwent multiple b-value DWI. The apparent diffusion coefficient (ADC), IVIM and DKI parameters were calculated using postprocessing software and compared between the malignant and benign groups. Receiver operating characteristic (ROC) analysis was performed for all parameters.
ADC and D were lower in malignant lesions than in benign lesions, while Kapp was higher ( < 0.05). The differences in D*, f, and Dapp between the two groups were not significant ( > 0.05). The areas under the curves (AUCs) of ADC, D, and Kapp were 0.816, 0.864, and 0.822. The combination of all the significant parameters yielded an AUC of 0.880. There were no significant differences in diagnostic efficacy among ADC, D, Kapp and the predictor factor (PRE).
In this study, traditional DWI (ADC), IVIM (D), and DKI (Kapp) all had good diagnostic performance in differentiating malignant lung lesions from benign lesions, but the combination of ADC, D, and Kapp value had better diagnostic efficacy than these parameters alone.
比较传统扩散加权成像（DWI）、体素内不相干运动成像（IVIM）和扩散峰度成像（DKI）在鉴别肺良恶性病变中的作用。
55例连续的肺部病变患者接受了多b值DWI检查。使用后处理软件计算表观扩散系数（ADC）、IVIM和DKI参数，并在恶性和良性组之间进行比较。对所有参数进行受试者操作特征（ROC）分析。
恶性病变的ADC和D低于良性病变，而Kapp则更高（P<0.05）。两组之间D*、f和Dapp的差异无统计学意义（P>0.05）。ADC、D和Kapp的曲线下面积（AUC）分别为0.816、0.864和0.822。所有显著参数的组合产生的AUC为0.880。ADC、D、Kapp和预测因子（PRE）之间的诊断效能无显著差异。
在本研究中，传统DWI（ADC）、IVIM（D）和DKI（Kapp）在鉴别肺恶性病变和良性病变方面均具有良好的诊断性能，但ADC、D和Kapp值的组合比这些参数单独使用具有更好的诊断效能。
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