Feng Chao, Chen Jing, Ye Wenxin, Liao Kaisen, Wang Zhanshi, Song Xiaofei, Qiao Mingqiang
Department of Urology, Tongde Hospital of Zhejiang Province, Hangzhou, China.
The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China.
Front Bioeng Biotechnol. 2022 Jan 20;10:833920. doi: 10.3389/fbioe.2022.833920. eCollection 2022.
Resveratrol, a bioactive natural product found in many plants, is a secondary metabolite and has attracted much attention in the medicine and health care products fields due to its remarkable biological activities including anti-cancer, anti-oxidation, anti-aging, anti-inflammation, neuroprotection and anti-glycation. However, traditional chemical synthesis and plant extraction methods are impractical for industrial resveratrol production because of low yield, toxic chemical solvents and environmental pollution during the production process. Recently, the biosynthesis of resveratrol by constructing microbial cell factories has attracted much attention, because it provides a safe and efficient route for the resveratrol production. This review discusses the physiological functions and market applications of resveratrol. In addition, recent significant biotechnology advances in resveratrol biosynthesis are systematically summarized. Furthermore, we discuss the current challenges and future prospects for strain development for large-scale resveratrol production at an industrial level.
白藜芦醇是一种存在于多种植物中的生物活性天然产物，是一种次生代谢产物，因其具有抗癌、抗氧化、抗衰老、抗炎、神经保护和抗糖化等显著生物活性，在医药和保健品领域备受关注。然而，传统的化学合成和植物提取方法因产量低、生产过程中使用有毒化学溶剂以及环境污染等问题，不适用于工业化生产白藜芦醇。近年来，通过构建微生物细胞工厂生物合成白藜芦醇备受关注，因为它为白藜芦醇的生产提供了一条安全高效的途径。本文综述了白藜芦醇的生理功能和市场应用。此外，系统总结了白藜芦醇生物合成方面近期的重大生物技术进展。此外，我们还讨论了工业规模生产白藜芦醇菌株开发目前面临的挑战和未来前景。
