Almeida Tamires Cunha, Silva Glenda Nicioli da
Universidade Federal de Ouro Preto, Laboratório de Pesquisas Clínicas, Ouro Preto, MG, Brazil.
Genet Mol Biol. 2021 Mar 22;44(1):e20200371. doi: 10.1590/1678-4685-GMB-2020-0371. eCollection 2021.
Bladder cancer has a high incidence worldwide and is the most common genitourinary cancer. The treatment of bladder cancer involves surgery and chemotherapy; however high failure rates and toxicity are observed. In this context, the search of new drugs aiming a more effective treatment is extremely necessary. Natural products are an important source of compounds with antiproliferative effects. Resveratrol is a naturally occurring plant polyphenol whose anticancer activity has been demonstrated in different types of cancer. This review summarizes the in vitro and in vivo studies using models of bladder cancer treated with resveratrol and discusses its different mechanisms of action.
膀胱癌在全球范围内发病率较高，是最常见的泌尿生殖系统癌症。膀胱癌的治疗包括手术和化疗；然而，观察到较高的失败率和毒性。在这种情况下，寻找更有效治疗方法的新药极为必要。天然产物是具有抗增殖作用的化合物的重要来源。白藜芦醇是一种天然存在的植物多酚，其抗癌活性已在不同类型的癌症中得到证实。本综述总结了使用白藜芦醇治疗膀胱癌模型的体外和体内研究，并讨论了其不同的作用机制。
