Shen Qiudi, Qi Yansong, Kong Yangzhi, Bao Huricha, Wang Yifan, Dong Alideertu, Wu Haixia, Xu Yongsheng
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, China.
Department of Orthopedics, Inner Mongolia People's Hospital, Hohhot, China.
Front Bioeng Biotechnol. 2022 Jan 20;9:795425. doi: 10.3389/fbioe.2021.795425. eCollection 2021.
Treating bone defects coupled with pathogen infections poses a formidable challenge to clinical medicine. Thus, there is an urgent need to develop orthopedic implants that provide excellent antibacterial and osteogenic properties. Of the various types, copper-based biomaterials capable of both regenerating bone and fighting infections are an effective therapeutic strategy for bone tissue engineering and therefore have attracted significant research interest. This review examines the advantages of copper-based biomaterials for biological functions and introduces these materials' antibacterial mechanisms. We summarize current knowledge about the application of copper-based biomaterials with antimicrobial and osteogenic properties in the prevention and treatment of bone infection and discuss their potential uses in the field of orthopedics. By examining both broad and in-depth research, this review functions as a practical guide to developing copper-based biomaterials and offers directions for possible future work.
治疗伴有病原体感染的骨缺损对临床医学构成了巨大挑战。因此，迫切需要开发具有优异抗菌和成骨性能的骨科植入物。在各种类型中，能够再生骨骼并对抗感染的铜基生物材料是骨组织工程的一种有效治疗策略，因此引起了广泛的研究兴趣。本文综述了铜基生物材料在生物学功能方面的优势，并介绍了这些材料的抗菌机制。我们总结了目前关于具有抗菌和成骨性能的铜基生物材料在预防和治疗骨感染中的应用的知识，并讨论了它们在骨科领域的潜在用途。通过考察广泛而深入的研究，本文为开发铜基生物材料提供了实用指南，并为未来可能的工作指明了方向。
