Wei Daixu, Tan Youguo
Zigong Affiliated Hospital of Southwest Medical University, Zigong Psychiatric Research Center, Zigong Institute of Brain Science, Zigong Sichuan, 643002, P. R. China.
Department of Life Sciences and Medicine, Northwest University, Xi'an Shaanxi, 710069, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Aug 15;37(8):909-917. doi: 10.7507/1002-1892.202211018.
To review the research progress of natural biomaterial polyhydroxyalkanoate (PHA) in orthopedics.
The literature concerning PHA devices for bone defects, bone repair, and bone neoplasms, respectively, in recent years was extensively consulted. The three aspects of the advantages of PHA in bone repair, the preparation of PHA medical devices for bone repair and their application in orthopedics were discussed.
Due to excellent biodegradability, biocompatibility, and potential osteoinduction, PHA is a kind of good bone repair material. In addition to the traditional PHA medical implants, the use of electrostatic spinning and three-dimensional printing can be designed to various functional PHA medical devices, in order to meet the orthopedic clinical demands, including the bone regeneration, minimally invasive bone tissue repair by injection, antibacterial bone repair, auxiliary establishment of three-dimensional bone tumor model, directed osteogenic differentiation of stem cells, .
At present, PHA is a hotspot of biomaterials for translational medicine in orthopedics. Although they have not completely applied in the clinic, the advantages of repair in bone defects have been gradually reflected in tissue engineering, showing an application prospect in orthopedics.
综述天然生物材料聚羟基脂肪酸酯（PHA）在骨科领域的研究进展。
广泛查阅近年来分别关于PHA用于骨缺损、骨修复及骨肿瘤的文献。探讨了PHA在骨修复中的优势、用于骨修复的PHA医疗器械的制备及其在骨科中的应用这三个方面。
由于具有优异的生物降解性、生物相容性和潜在的骨诱导性，PHA是一种良好的骨修复材料。除了传统的PHA医用植入物外，利用静电纺丝和三维打印可设计出各种功能性PHA医疗器械，以满足骨科临床需求，包括骨再生、注射微创骨组织修复、抗菌骨修复、辅助建立三维骨肿瘤模型、干细胞定向成骨分化等。
目前，PHA是骨科转化医学中生物材料的研究热点。虽然其尚未完全应用于临床，但在骨缺损修复方面的优势已在组织工程中逐渐体现，在骨科领域展现出应用前景。
