Li Yuanchao, Wang Rupeng
Department of Dermatology, Rheumatology, and Immunology, Xinqiao Hospital of Army Medical University, Chongqing, China.
Front Med (Lausanne). 2022 Jan 20;8:798294. doi: 10.3389/fmed.2021.798294. eCollection 2021.
The advantage of pulsed dye laser (PDL) for the treatment of rosacea is not yet clear. This meta-analysis compared the curative effect of PDL to neodymium:yttrium-aluminum-garnet (Nd:YAG) laser for the treatment of rosacea.
The PubMed, Embase, and Cochrane Library databases were searched for clinical studies on the efficacy of PDL for the treatment of rosacea through October 13, 2021, and heterogeneity tests among studies were evaluated. Meta-analysis was conducted to combine the effects of physicians' clinical assessments, patient global assessment, erythema index, and visual analog scale.
A total of 326 articles were obtained from three databases and ten articles were finally included. The clinical improvements of >50% clearance of up to 68.6% in the PDL group and 71.4% in the control group, and the subjective satisfaction rate of patients in the PDL group of 88.6% compared to 91.4% in the Nd:YAG group, but there were no significant differences in the rates of patients with rosacea with clinical improvement (>50% clearance) (relative risk [RR] = 0.94, 95% confidence interval [CI]: 0.75-1.17, = 0.578) or patient subjective satisfaction rate (RR = 0.96, 95% CI: 0.70-1.33, = 0.808) between PDL and Nd:YAG groups for rosacea treatment. Also, the pain score for PDL and Nd:YAG were not significant (mean = 3.07, 95% CI: 1.82-4.32, = 0.115).
Two treatments all showed clinical efficacy and patient satisfaction for the treatment of rosacea, with no significant differences observed between treatments. The pain scores for PDL and Nd:YAG were not significant.
脉冲染料激光（PDL）治疗酒渣鼻的优势尚不清楚。本荟萃分析比较了PDL与钕：钇铝石榴石（Nd:YAG）激光治疗酒渣鼻的疗效。
检索PubMed、Embase和Cochrane图书馆数据库中截至2021年10月13日关于PDL治疗酒渣鼻疗效的临床研究，并评估研究间的异质性。进行荟萃分析以综合医生临床评估、患者整体评估、红斑指数和视觉模拟量表的效果。
从三个数据库共获得326篇文章，最终纳入10篇。PDL组临床改善（清除率>50%）高达68.6%，对照组为71.4%；PDL组患者主观满意率为88.6%，Nd:YAG组为91.4%。但在酒渣鼻临床改善（清除率>50%）的患者比例（相对危险度[RR]=0.94，95%置信区间[CI]：0.75-1.17，P=0.578）或患者主观满意率（RR=0.96，95%CI：0.70-1.33，P=0.808）方面，PDL组和Nd:YAG组治疗酒渣鼻无显著差异。此外，PDL和Nd:YAG的疼痛评分也无显著差异（均值=3.07，95%CI：1.82-4.32，P=0.115）。
两种治疗方法对酒渣鼻治疗均显示出临床疗效和患者满意度，治疗之间未观察到显著差异。PDL和Nd:YAG的疼痛评分无显著差异。
