Department of Dermatology, The George Washington Medical Faculty Associates, 2150 Pennsylvania Avenue Northwest, 2B-427, Washington, DC 20037, USA.
Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1071, USA.
Dermatol Clin. 2018 Apr;36(2):87-92. doi: 10.1016/j.det.2017.11.002. Epub 2017 Dec 16.
Rosacea is a common inflammatory skin disease with a multifaceted pathophysiology, including environmental stressors and neurovascular and immune dysfunction affected by the presence of pathogens. The genetic component of this disorder is not well understood. However, a possible genetic origin in Northern European descendants, family inheritance, twin concordance, and genetic associations with autoimmune disorders attest the genetic predisposition to rosacea. Currently, one single-nucleotide polymorphism has been identified in association with rosacea and is intergenic between HLA-DRA and BTNL2. Additional associations with HLA alleles and immune-mediated disorders support the role of immune-regulating genes and innate and adaptive immunity in rosacea.
酒渣鼻是一种常见的炎症性皮肤疾病，其发病机制具有多面性，包括环境应激源以及受病原体影响的神经血管和免疫功能障碍。这种疾病的遗传组成部分尚不清楚。然而，北欧后裔中可能存在遗传起源、家族遗传、双胞胎一致性以及与自身免疫性疾病的遗传关联，都证明了酒渣鼻具有遗传易感性。目前，已经确定了与酒渣鼻相关的一个单核苷酸多态性，位于 HLA-DRA 和 BTNL2 之间的基因间区域。与 HLA 等位基因和免疫介导性疾病的其他关联支持免疫调节基因以及先天和适应性免疫在酒渣鼻中的作用。
