Pater J L, Weir L
J Clin Oncol. 1986 Mar;4(3):346-52. doi: 10.1200/JCO.1986.4.3.346.
Twenty-one randomized trials of empiric antibiotic therapy in febrile neutropenic patients were reviewed and scored by methods suggested by Chalmers. In general, the scores were low, indicating that many of these articles failed to meet currently suggested methodologic standards for publication of results of clinical trials. Particularly striking was the lack of attention paid to statistical issues, such as power, exclusions, and repeated analyses. In addition, there appears to be a need for a better-developed system for assessing response in these circumstances.
我们采用查尔默斯提出的方法，对21项关于发热性中性粒细胞减少患者经验性抗生素治疗的随机试验进行了综述和评分。总体而言，评分较低，这表明这些文章中有许多未能达到目前建议的临床试验结果发表的方法学标准。尤其引人注目的是，对统计学问题缺乏关注，如检验效能、排除标准和重复分析。此外，似乎需要一个更完善的系统来评估这些情况下的反应。
