Fang Ziyan, Méresse Stéphane
Aix Marseille University, CNRS, INSERM, CIML, Marseille, France.
Microb Cell. 2021 Dec 27;9(2):24-41. doi: 10.15698/mic2022.02.769. eCollection 2022 Feb 7.
e are bacteria that cause moderate to severe infections in humans, depending on the strain and the immune status of the infected host. These pathogens have the particularity of residing in the cells of the infected host. They are usually found in a vacuolar compartment that the bacteria shape with the help of effector proteins. Following invasion of a eukaryotic cell, the bacterial vacuole undergoes maturation characterized by changes in localization, composition and morphology. In particular, membrane tubules stretching over the microtubule cytoskeleton are formed from the bacterial vacuole. Although these tubules do not occur in all infected cells, they are functionally important and promote intracellular replication. This review focuses on the role and significance of membrane compartment remodeling observed in infected cells and the bacterial and host cell pathways involved.
某些细菌会根据菌株和受感染宿主的免疫状态，在人类中引发中度至重度感染。这些病原体的特殊之处在于它们寄生于受感染宿主的细胞内。它们通常存在于一个液泡区室中，细菌借助效应蛋白塑造该液泡区室。真核细胞被入侵后，细菌液泡会经历成熟过程，其特征表现为定位、组成和形态的变化。特别是，细菌液泡会形成延伸于微管细胞骨架之上的膜性小管。尽管并非所有受感染细胞都会出现这些小管，但它们在功能上很重要，可促进细胞内复制。本综述着重探讨在受感染细胞中观察到的膜区室重塑的作用和意义，以及涉及的细菌和宿主细胞途径。
