全球糖尿病足溃疡研究趋势（2004-2020）：对研究人员的建议。

OBJECTIVES: Diabetic foot ulcer (DFU) is one of the devastating complications of diabetes. It has high mortality and disability rates. The number of research articles on DFUs has increased. This study was designed to explore the global trends and research hotspots of DFUs to benefit researchers in shaping future research directions. METHODS: Literatures relating to DFU from 2004 to 2020 were retrieved from the Science Citation Index Expanded (SCI-expanded) of Web of Science Core Collection (WoSCC). The current status of DFU research (including publications, journals, the performances of relevant countries, institutions, and authors and the research trends and hotspots of DFU) was analyzed with the WoSCC. VOSviewer v1.6.10.0 was utilised for cocitation, coauthorship, cooccurrence analyses, and bibliographic coupling. RESULTS: A total of 5869 publications on DFUs were retrieved. We performed a longitudinal review of publications over 17 years: 4500 articles and 865 review articles on DFUs published from 2004 to 2020 were analyzed. The total citation was 107,296. The USA ( = 1866), England ( = 606), and China ( = 599) were the three largest contributors. The University of Washington had the greatest number of publications within this time period ( = 103), and it had the most cooperative units and was in the core position in all research institutions, followed by the University of Manchester ( = 94) and the University of Miami ( = 92). Armstrong DG (91/1.69%) and Lavery LA (55/1.19%) should be regarded as scholars who have made outstanding contributions. The top journal with the greatest total link strength was . Analysis showed that the global research hotspots of DFU focused on lower limb amputation, diabetic foot infection, and treatment and management of DFU. Studies on osteomyelitis, wound therapy and management, multidisciplinary integration and mechanism of DFUs, and its related diseases are the research fronts that should be closely watched in the future. CONCLUSIONS: This study revealed the current research status and hotspots in the domain of DFU over the past 17 years, which can help researchers to further pinpoint potential perspectives on hot topics and research frontiers.

目的：糖尿病足溃疡（DFU）是糖尿病的严重并发症之一，具有较高的死亡率和致残率。有关 DFU 的研究文章数量不断增加。本研究旨在探讨 DFU 的全球趋势和研究热点，以帮助研究人员确定未来的研究方向。

方法：从 Web of Science 核心合集（WoSCC）的科学引文索引扩展版（SCI-expanded）中检索了 2004 年至 2020 年与 DFU 相关的文献。利用 WoSCC 分析了 DFU 研究的现状（包括出版物、期刊、相关国家、机构、作者的表现以及 DFU 的研究趋势和热点）。VOSviewer v1.6.10.0 用于共被引、共著、共现分析和文献耦合。

结果：共检索到 5869 篇关于 DFU 的出版物。我们对 17 年来的出版物进行了纵向回顾：分析了 2004 年至 2020 年期间发表的 4500 篇文章和 865 篇综述文章。总引文量为 107296。美国（ = 1866）、英国（ = 606）和中国（ = 599）是前三大贡献者。在这段时间内，华盛顿大学发表的文章数量最多（ = 103），且它在所有研究机构中合作单位最多，处于核心地位，其次是曼彻斯特大学（ = 94）和迈阿密大学（ = 92）。Armstrong DG（91/1.69%）和 Lavery LA（55/1.19%）应被视为做出杰出贡献的学者。总链接强度最大的顶级期刊是。分析表明，DFU 的全球研究热点集中在下肢截肢、糖尿病足感染以及 DFU 的治疗和管理上。骨髓炎、伤口治疗和管理、多学科整合和 DFU 机制以及相关疾病的研究是未来需要密切关注的研究前沿。

结论：本研究揭示了过去 17 年中 DFU 领域的当前研究状况和热点，这有助于研究人员进一步确定热门话题和研究前沿的潜在视角。