英国队列研究中患有痴呆症的养老院居民：患病率、发病率及其与睡眠障碍的关联

Care home residents with dementia: Prevalence, incidence, and associations with sleep disturbance in an English cohort study.

作者信息

Webster Lucy A, Costafreda Sergi G, Barber Julie A, Kyle Simon D, Livingston Gill

机构信息

Division of Psychiatry UCL London UK.

Camden and Islington NHS Foundation Trust London UK.

出版信息

Alzheimers Dement (N Y). 2022 Feb 1;8(1):e12251. doi: 10.1002/trc2.12251. eCollection 2022.

DOI:10.1002/trc2.12251

PMID:35128034

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8804598/

Abstract

INTRODUCTION

People living with dementia in care homes often have sleep disturbances, but little is known about incidence and importance.

METHODS

We interviewed 1483 participants in 97 care homes and report prevalence, 1-year incidence, and baseline associations of clinically significant sleep disturbance in people with dementia.

RESULTS

Baseline prevalence of clinically significant sleep disturbance was 13.7% (200/1460); 31.3% (457/1462) had them at least once over 16 months. One-year incidence was 25.2%. At baseline, residents with sleep disturbance had lower quality of life (mean difference -4.84; 95% confidence interval [CI] -6.53 to -3.16) and were more frequently prescribed sleep medications (odds ratio 1.75; CI 1.17 to 2.61) than other residents.

DISCUSSION

Approximately one-third of care home residents with dementia have or develop sleep disturbances over 1 year. These are associated with lower quality of life and prescription of sedatives, which may have negative outcomes; therefore, it is important to develop effective treatments.

摘要

引言

养老院中的痴呆症患者常常存在睡眠障碍，但对其发生率及重要性却知之甚少。

方法

我们对97家养老院的1483名参与者进行了访谈，并报告了痴呆症患者临床上显著睡眠障碍的患病率、1年发生率及基线关联情况。

结果

临床上显著睡眠障碍的基线患病率为13.7%（200/1460）；在16个月内，31.3%（457/1462）的患者至少出现过一次此类情况。1年发生率为25.2%。在基线时，有睡眠障碍的居民生活质量较低（平均差异-4.84；95%置信区间[CI]-6.53至-3.16），且比其他居民更频繁地被开具睡眠药物（优势比1.75；CI 1.17至2.61）。