Yi Jonathan S, Satterfield Kellie R, Choi Catherine S, Boos Markus D, Cabrera Michelle T
Department of Ophthalmology, University of Washington, Seattle, WA, USA.
Newton Wellesley Eye Associates in Newton, Massachusetts, USA.
Am J Ophthalmol Case Rep. 2022 Jan 22;25:101335. doi: 10.1016/j.ajoc.2022.101335. eCollection 2022 Mar.
Periocular molluscum contagiosum can cause a chronic secondary follicular conjunctivitis or keratoconjunctivitis that rarely leads to corneal scarring and visual impairment. We describe two cases of follicular conjunctivitis due to periocular molluscum contagiosum that were successfully treated with topical adapalene 0.1%.
Case 1 is a 9-year old female with a history of leg molluscum contagiosum who presented with three 1mm flesh-colored umbilicated papules on the periocular skin of the right eye with associated follicular conjunctivitis and diffuse corneal punctate epithelial erosions. Ocular symptoms were persistent for 6 months. Case 2 is a 4-year old female with a 3-month history of right periocular bumps and one month of conjunctival redness with eyelid edema. Examination revealed umbilicated flesh colored nodules on the right upper and lower eyelids with associated trace conjunctival injection. Both patients experienced rapid resolution of both eyelid involvement and conjunctivitis following the use of twice daily topical adapalene 0.1% to the eyelid lesions, with no reported side effects.
Topical adapalene 0.1% is a cost-effective, convenient, and non-toxic over-the-counter retinoid cream that should be considered for first-line therapy in the treatment of periocular molluscum contagiosum and any associated conjunctivitis.
眼周传染性软疣可引起慢性继发性滤泡性结膜炎或角结膜炎，很少导致角膜瘢痕形成和视力损害。我们描述了两例因眼周传染性软疣引起的滤泡性结膜炎，使用0.1%的外用阿达帕林成功治愈。
病例1是一名9岁女性，有腿部传染性软疣病史，右眼眼周皮肤出现三个1毫米大小的肉色脐状丘疹，伴有滤泡性结膜炎和弥漫性角膜点状上皮糜烂。眼部症状持续6个月。病例2是一名4岁女性，有3个月的右眼眼周肿物病史，1个月的结膜充血伴眼睑水肿。检查发现右上睑和下睑有脐状肉色结节，伴有轻度结膜充血。两名患者在每天两次将0.1%的外用阿达帕林涂抹于眼睑病变部位后，眼睑病变和结膜炎均迅速消退，且未报告有副作用。
0.1%的外用阿达帕林是一种经济有效、方便且无毒的非处方维甲酸乳膏，在治疗眼周传染性软疣及任何相关结膜炎时应考虑作为一线治疗药物。
