Scruggs Brittni A, Ni Shuibin, Nguyen Thanh-Tin P, Ostmo Susan, Chiang Michael F, Jia Yali, Huang David, Jian Yifan, Campbell J Peter
Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, OR, USA.
National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Ophthalmol Sci. 2022 Mar;2(1). doi: 10.1016/j.xops.2021.100094. Epub 2022 Jan 11.
To determine whether handheld widefield optical coherence tomography (OCT) can be used to document retinopathy of prematurity (ROP) stage while using scleral depression to improve peripheral views.
Prospective observational study.
Consecutive neonates admitted to the neonatal intensive care unit (NICU) in a single academic medical center who also met criteria for ROP screening and consented for research imaging.
Scleral depression was combined with widefield OCT using an investigational 400-kHz, 55-degree field of view handheld OCT during routine ROP screening from October 28, 2020 to March 03, 2021.
Acquisition of and B-scan imaging of the peripheral retina to objectively assess early vitreoretinal pathology, including the demarcation between vascularized and anterior avascular retina, the presence of early ridge formation, and small neovascular tufts.
Various stages of ROP were detected using a rapid acquisition OCT system. In one neonate, serial OCT imaging over a five-week period demonstrated accumulation of neovascular tufts with progression to stage 3 ROP with extraretinal fibrovascular proliferation along the ridge. Videography of this technique is included in this report for instructional purposes.
Serial examinations using widefield OCT and scleral depression is feasible and may improve detection and documentation of ROP disease progression. Earlier detection of ROP-related proliferation may prevent vitreoretinal traction, retinal detachment, and blindness.
确定在使用巩膜压迫法改善周边视野时，手持宽视野光学相干断层扫描（OCT）是否可用于记录早产儿视网膜病变（ROP）分期。
前瞻性观察性研究。
在单一学术医疗中心新生儿重症监护病房（NICU）收治的连续新生儿，这些新生儿也符合ROP筛查标准并同意进行研究成像。
在2020年10月28日至2021年3月3日的常规ROP筛查期间，使用研究性的400千赫、55度视野手持OCT将巩膜压迫法与宽视野OCT相结合。
获取周边视网膜的A扫描和B扫描成像，以客观评估早期玻璃体视网膜病变，包括血管化视网膜与前部无血管视网膜之间的界限、早期嵴形成的存在以及小的新生血管簇。
使用快速采集OCT系统检测到了不同阶段的ROP。在一名新生儿中，为期五周的连续OCT成像显示新生血管簇积聚，并进展为3期ROP，沿嵴出现视网膜外纤维血管增殖。本报告包含该技术的视频记录以供教学使用。
使用宽视野OCT和巩膜压迫法进行连续检查是可行的，可能会改善ROP疾病进展的检测和记录。早期检测ROP相关增殖可能预防玻璃体视网膜牵拉、视网膜脱离和失明。
