Aldine Amro Saad, Ogilvie Amy, Wemmie John, Kent James, Schultz Jordan, Long Jeffrey D, Kamholz John, Sajjad Hassan, Kline Joel, Shaw Emily, Voss Michelle, Paulsen Jane S, Magnotta Vincent A
Department of Radiology, Ochsner LSU Health Shreveport Academic Medical Center, Shreveport, LA, 71103, USA.
Department of Biostatistics, The University of Iowa, Iowa City, IA, 52240, USA.
SVOA Neurol. 2021;2(1):6-36. Epub 2021 Feb 3.
While it has been shown that aerobic exercise interventions are well tolerated in participants with the Huntington disease (HD) gene mutation, no study to date has tested whether an aerobic exercise intervention benefits brain structure and function in pre-manifest HD.
In this study we utilized magnetic resonance (MR) imaging techniques to assess the efficacy of moderate-to-vigorous exercise treatment relative to active stretching and toning control.
Forty pre-manifest participants with confirmed HD gene expansion were recruited into a two-arm intervention study that included a moderate-to-vigorous intensity home-based walking exercise intervention (N=34) and an active stretching and toning control intervention (N=6). Participants were assessed at baseline and after 26 weeks in one of the two study arms.
25 of the 34 (74%) participants assigned to the moderate-to-vigorous intensity group completed the intervention while 4 of the 6 (67%) participants in the stretching and toning intervention completed the study. The primary analyses compared the two arms of the study and found no statistical differences between the groups. Both groups were found to have improved their cardiorespiratory fitness as assessed by maximal oxygen uptake (VOmax). A secondary analysis combined the two arms of the study and there was a significant relationship (p<0.05) between change in VOmax and change in brain structure.
Though this study did not show efficacy for the exercise intervention, secondary results suggest that aerobic exercise interventions increasing cardiorespiratory fitness may be a potential way to slow progression in pre-manifest HD.
虽然已有研究表明有氧运动干预对携带亨廷顿舞蹈病（HD）基因突变的参与者耐受性良好，但迄今为止尚无研究测试有氧运动干预对临床前HD患者脑结构和功能是否有益。
在本研究中，我们利用磁共振（MR）成像技术评估中度至剧烈运动治疗相对于主动拉伸和塑形对照的疗效。
40名临床前确诊HD基因扩增的参与者被纳入一项双臂干预研究，其中包括中度至剧烈强度的居家步行运动干预（N = 34）和主动拉伸与塑形对照干预（N = 6）。参与者在两个研究组之一的基线和26周后接受评估。
分配到中度至剧烈强度组的34名参与者中有25名（74%）完成了干预，而拉伸与塑形干预组的6名参与者中有4名（67%）完成了研究。主要分析比较了研究的两组，发现两组之间无统计学差异。通过最大摄氧量（VOmax）评估发现两组的心肺适能均有所改善。一项次要分析将研究的两组合并，发现VOmax变化与脑结构变化之间存在显著关系（p<0.05）。
虽然本研究未显示运动干预的疗效，但次要结果表明，提高心肺适能的有氧运动干预可能是减缓临床前HD进展的一种潜在方法。
