Quinn Lori, Hamana Katy, Kelson Mark, Dawes Helen, Collett Johnny, Townson Julia, Roos Raymund, van der Plas Anton Adriaan, Reilmann Ralf, Frich Jan C, Rickards Hugh, Rosser Anne, Busse Monica
School of Healthcare Sciences, Cardiff University, UK; Department of Biobehavioral Sciences, Teachers College, Columbia University, USA.
School of Healthcare Sciences, Cardiff University, UK.
Parkinsonism Relat Disord. 2016 Oct;31:46-52. doi: 10.1016/j.parkreldis.2016.06.023. Epub 2016 Jul 1.
This study aimed to evaluate the feasibility and benefit of a structured exercise intervention in people with Huntington's Disease (HD).
This study was conducted at 6 sites, and participants were randomized into either exercise or control (usual care) groups, and were assessed at baseline, 13 and 26 weeks. The intervention was a 12 week, three times per week progressive exercise program, including aerobic (stationary cycling) and upper and lower body strengthening exercise with tapered 1:1 support for 20 of 36 sessions.
314 adults were assessed for eligibility: 248 did not meet inclusion criteria, 34 declined, and 32 were recruited and randomized. Three individuals in the intervention group were withdrawn within the first month due to concomitant medical conditions, resulting in 14 participants in intervention and 15 in control groups. There were two AEs in the intervention group, both related to previous medical conditions, and there were two SAEs, both in the control group. The intervention group had better fitness (predicted VO max difference: 492.3 ml min, 95% CI: [97.1, 887.6]), lower UHDRS mMS (difference 2.9 points, 95% [-5.42, -0.32]) and lower weight at Week 13 (difference 2.25 kg, 95% CI: [-4.47, -0.03]).
This study demonstrates that a short-term exercise intervention is safe and feasible. Individuals with HD may benefit from structured exercise, and intensity, monitoring and support may be key factors in optimizing response. Larger scale trials are now required to fully elucidate the extended clinical potential of exercise in HD.
Current Controlled Trials ISRCTN11392629.
本研究旨在评估结构化运动干预对亨廷顿舞蹈症（HD）患者的可行性和益处。
本研究在6个地点开展，参与者被随机分为运动组或对照组（常规护理），并在基线、第13周和第26周进行评估。干预措施为一项为期12周、每周三次的渐进性运动计划，包括有氧运动（固定自行车）以及上下肢力量训练，在36节课程中的20节提供一对一的逐步减少的支持。
对314名成年人进行了资格评估：248人不符合纳入标准，34人拒绝参与，32人被招募并随机分组。干预组中有3人在第一个月内因并发疾病退出，最终干预组有14名参与者，对照组有15名参与者。干预组出现了2例不良事件，均与既往疾病有关，对照组出现了2例严重不良事件。干预组的体能更好（预测最大摄氧量差异：492.3毫升/分钟，95%置信区间：[97.1, 887.6]），第13周时统一亨廷顿舞蹈病评定量表运动评分更低（差异2.9分，95%置信区间：[-5.42, -0.32]），体重也更低（差异2.25千克，95%置信区间：[-4.47, -0.03]）。
本研究表明短期运动干预是安全可行的。HD患者可能从结构化运动中获益，强度、监测和支持可能是优化反应的关键因素。现在需要更大规模的试验来充分阐明运动在HD中的扩展临床潜力。试验注册：国际标准随机对照试验编号ISRCTN11392629。
