Nursing Care Research Center (NCRC), School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran.
Department of Neonatology, Ali Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2022 Jan 1;25(1):26-31. doi: 10.34172/aim.2022.05.
Recently, blood monocyte concentration has been introduced as an inventive biomarker for necrotizing enterocolitis (NEC) in low birth weight neonate; therefore, we aimed to examine and compare blood monocyte counts in preterm neonates with and without NEC.
A case-control study was conducted on 160 preterm neonates in Tehran during 2017. In this study, medical records and laboratory findings of 80 neonates with NEC (case) and 80 neonates (control), who were randomly chosen from among neonates who had survived NEC, were reviewed and CBC outcomes were compared between the groups.
We compared 80 cases and 80 controls. The mean gestational age in the NEC and control group was 30.78±2.33 and 31.41±2.16 weeks, respectively. The birth weights in the NEC and control group were 1500±488 and 1562±360 g, respectively. The mean age for developing NEC was 14.14±13.9 days. The absolute neutrophil count (ANC) and absolute lymphocyte count (ALC) did not differ statistically significantly between the two groups. The mean absolute white blood cells (WBC) in the NEC and control group were 11368±7957 and 8268±7505, respectively; absolute WBC was significantly different between the two groups (=0.001). The mean absolute monocyte count (AMC) in the NEC and control group were 262±193 and 518±691, respectively; the difference in absolute WBC was significant between the two groups (=0.002). Receiver operating characteristic of AMC values showed a diagnostic accuracy of 0.693 (95% CI: 0.612-0.773) for NEC and 0.738 (95% CI: 0.627-0.850) for stage II and III NEC.
The result of this study suggest that the concentration of blood monocyte could be an indicator for NEC in the preterm neonate. However, this result should be confirmed by other studies.
最近，血液单核细胞浓度已被引入作为低出生体重儿坏死性小肠结肠炎（NEC）的创新生物标志物；因此，我们旨在检查和比较患有和不患有 NEC 的早产儿的血液单核细胞计数。
2017 年在德黑兰对 160 名早产儿进行了病例对照研究。在这项研究中，回顾了 80 名患有 NEC（病例）和 80 名随机选择的存活 NEC 患儿（对照组）的患儿的病历和实验室检查结果，并比较了两组之间的 CBC 结果。
我们比较了 80 例病例和 80 例对照组。NEC 组和对照组的平均胎龄分别为 30.78±2.33 周和 31.41±2.16 周。NEC 组和对照组的出生体重分别为 1500±488 克和 1562±360 克。NEC 发病的平均年龄为 14.14±13.9 天。两组之间的绝对中性粒细胞计数（ANC）和绝对淋巴细胞计数（ALC）无统计学差异。NEC 组和对照组的平均绝对白细胞计数（WBC）分别为 11368±7957 和 8268±7505，绝对 WBC 两组之间有显著差异（=0.001）。NEC 组和对照组的平均绝对单核细胞计数（AMC）分别为 262±193 和 518±691，两组之间的绝对 WBC 差异有统计学意义（=0.002）。AMC 值的受试者工作特征曲线显示，NEC 的诊断准确性为 0.693（95%CI：0.612-0.773），而 II 期和 III 期 NEC 的诊断准确性为 0.738（95%CI：0.627-0.850）。
本研究结果表明，血液单核细胞浓度可作为早产儿 NEC 的指标。然而，这一结果需要其他研究的证实。
