Taily Irshad Maajid, Saha Debarshi, Banerjee Prabal
Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.
J Org Chem. 2022 Mar 4;87(5):2155-2166. doi: 10.1021/acs.joc.1c03108. Epub 2022 Feb 7.
Herein, we report a highly facile and unprecedented activation of 3-amido oxetanes to synthesize 2-oxazoline amide ethers using a transient electrophilic aza-oxyallyl cation as an activating as well as an alkylating agent under mild reaction conditions. The aza-oxyallyl cation driven intramolecular rearrangement of 3-amido oxetanes to 2-oxazolines is the hallmark of this transformation and is a new addition to the reactivity profile of aza-oxyallyl cations.
在此，我们报道了一种高度简便且前所未有的3-氨基氧杂环丁烷的活化反应，该反应在温和的反应条件下，使用瞬态亲电氮杂氧代烯丙基阳离子作为活化剂和烷基化剂来合成2-恶唑啉酰胺醚。氮杂氧代烯丙基阳离子驱动的3-氨基氧杂环丁烷向2-恶唑啉的分子内重排是这种转化的标志，也是氮杂氧代烯丙基阳离子反应活性谱中的新成员。
