Stefanou Maria Ioanna, Karachaliou Eleni, Chondrogianni Maria, Moschovos Christos, Bakola Eleni, Foska Aikaterini, Melanis Konstantinos, Andreadou Elisabeth, Voumvourakis Konstantinos, Papathanasiou Matilda, Boutati Eleni, Tsivgoulis Georgios
Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Rimini 1, Chaidari, 12462, Athens, Greece.
First Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Neurol Res Pract. 2022 Feb 8;4(1):6. doi: 10.1186/s42466-022-00172-1.
This correspondence comments on a published article presenting a case of rhombencephalitis following SARS-CoV-2-vaccination with the mRNA vaccine BNT162b2 (Pfizer/BioNTech). We also present the case of a 47-year-old man who developed Guillain-Barré-syndrome and a fulminant encephalomyelitis 28 days after immunization with Ad26.COV2.S (Janssen/Johnson & Johnson). Based on the presented cases, we underscore the importance of clinical awareness for early recognition of overlapping neuroimmunological syndromes following vaccination against SARS-CoV-2. Additionally, we propose that that role of autoantibodies against angiotensin-converting enzyme 2 (ACE2) and the cell-surface receptor neuropilin-1, which mediate neurological manifestations of SARS-CoV-2, merit further investigation in patients presenting with neurological disorders following vaccination against SARS-CoV-2.
本信函对一篇已发表的文章进行评论，该文章介绍了1例接种mRNA疫苗BNT162b2（辉瑞/ BioNTech）后发生的菱形脑炎病例。我们还介绍了1例47岁男性病例，该患者在接种Ad26.COV2.S（杨森/强生）疫苗28天后出现格林-巴利综合征和暴发性脑脊髓炎。基于所呈现的病例，我们强调临床意识对于早期识别接种SARS-CoV-2疫苗后重叠性神经免疫综合征的重要性。此外，我们建议，针对介导SARS-CoV-2神经表现的血管紧张素转换酶2（ACE2）和细胞表面受体神经纤毛蛋白-1的自身抗体在接种SARS-CoV-2疫苗后出现神经系统疾病的患者中的作用值得进一步研究。
