接种 SARS-CoV-2 疫苗后发生急性横贯性脊髓炎：病例报告及文献复习。
Acute transverse myelitis following SARS-CoV-2 vaccination: a case report and review of literature.
机构信息
B.J. Medical College and Civil Hospital, Ahmedabad, India.
Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal.
出版信息
J Neurol. 2022 Mar;269(3):1121-1132. doi: 10.1007/s00415-021-10785-2. Epub 2021 Sep 5.
OBJECTIVE
To report a unique case and literature review of post COVID-19 vaccination associated transverse myelitis and with abnormal MRI findings.
BACKGROUND
Coronavirus disease have been reported to be associated with several neurological manifestations such as stroke, Guillain-Barré syndrome, meningoencephalitis amongst others. There are only a few reported cases of transverse myelitis with the novel coronavirus (n-CoV-2). Here, we identify a post COVID-19 vaccination patient diagnosed with acute transverse myelitis.
METHOD
A retrospective chart review of a patient diagnosed with post SARS-CoV-2 vaccination acute transverse myelitis, and a review of literature of all the reported cases of other post vaccination and transverse myelitis, from December 1st, 2010 till July 15th, 2021, was performed.
CONCLUSION
To our knowledge, this is the one of early reported case of transverse myelitis and with post SARS-CoV-2 vaccination, who responded well to plasmapheresis. Further studies would be recommended to identify the underlying correlation between COVID-19 vaccination and transverse myelitis.
目的
报告一例 COVID-19 疫苗接种后相关的急性横贯性脊髓炎病例，并进行文献复习，该病例伴有异常的 MRI 发现。
背景
冠状病毒病已被报道与多种神经系统表现相关，如中风、吉兰-巴雷综合征、脑膜脑炎等。仅有少数新型冠状病毒（n-CoV-2）相关急性横贯性脊髓炎的报道病例。在这里，我们鉴定了一例 COVID-19 疫苗接种后发生急性横贯性脊髓炎的患者。
方法
对一例诊断为 SARS-CoV-2 疫苗接种后急性横贯性脊髓炎的患者进行回顾性病历审查，并对 2010 年 12 月 1 日至 2021 年 7 月 15 日期间所有报告的其他疫苗接种后和横贯性脊髓炎病例的文献进行了回顾。
结论
据我们所知，这是首例报告的 COVID-19 疫苗接种后发生的急性横贯性脊髓炎病例之一，对血浆置换反应良好。建议进一步研究以确定 COVID-19 疫苗接种与横贯性脊髓炎之间的潜在相关性。
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