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长期苯妥英钠使用导致进行性呼吸困难。

Longstanding Phenytoin Use as a Cause of Progressive Dyspnea.

机构信息

Department of Medicine, Mount Auburn Hospital, Cambridge, MA; Harvard Medical School, Boston, MA.

Department of Medicine, Mount Auburn Hospital, Cambridge, MA; Harvard Medical School, Boston, MA.

出版信息

Chest. 2022 Feb;161(2):e91-e96. doi: 10.1016/j.chest.2021.08.079.

DOI:10.1016/j.chest.2021.08.079
PMID:35131079
Abstract

A 54-year-old South African man with a medical history of type 2 diabetes mellitus, seizure disorder, OSA, and latent TB presented to the ER with gradually progressive dyspnea over months. He also reported occasional dry cough and fatigue at presentation but denied fever, chills, chest pain, leg swelling, palpitations, or lightheadedness. He was treated with a course of levofloxacin for presumed community-acquired pneumonia as an outpatient without improvement and had tested negative for COVID-19. He denied occupational or environmental exposures or sick contacts, though he had traveled back to South Africa 1 year before presentation. He had complex partial seizures for the past 22 years, which had been well controlled on phenytoin (300 mg daily). His other home medications included dulaglutide, sertraline, and atorvastatin and had no recent changes. He quit smoking 30 years ago after smoking one pack per day for 10 years.

摘要

一位 54 岁南非男性,有 2 型糖尿病、癫痫、OSA 和潜伏性结核病史,因数月来逐渐加重的呼吸困难到急诊就诊。他还报告在就诊时偶尔有干咳和疲劳,但无发热、寒战、胸痛、腿部肿胀、心悸或头晕。他曾因疑似社区获得性肺炎在门诊接受左氧氟沙星治疗,但无改善,并且 COVID-19 检测结果为阴性。他否认职业或环境暴露或患病接触者,但在就诊前 1 年曾返回南非。他过去 22 年有复杂部分性癫痫发作,苯妥英(300 毫克每日)控制良好。他的其他家用药物包括度拉糖肽、舍曲林和阿托伐他汀,并且最近没有变化。他在 30 年前戒烟,此前每天吸一包烟,持续了 10 年。

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