Tikhonova N E, Alekseeva G G
Probl Endokrinol (Mosk). 1986 Jan-Feb;32(1):22-5.
In 15 patients with the normal body mass and disturbed glucose tolerance a glycemia level was higher and insulin levels lower than in 10 healthy persons in the first 20 min after i. v. insulin injection (1.2 units per 1 m2 of the body surface). It was suggestive of resistance to insulin in such patients. The level of glucagon in the blood plasma after insulin injection rose in the patients as well as in healthy persons indicating an unchanged response of pancreatic alpha-cells to insulin in this type of diabetes mellitus. A growth hormone level in the blood after insulin injection bid not significantly change in both groups. Glucose homeostasis after insulin injection was regulated not by the growth hormone but mainly by glucagon.
在15名体重正常但糖耐量受损的患者中，静脉注射胰岛素（每1平方米体表面积1.2单位）后的前20分钟内，血糖水平高于10名健康人，胰岛素水平低于健康人。这表明此类患者存在胰岛素抵抗。胰岛素注射后，患者和健康人的血浆胰高血糖素水平均升高，表明在这类糖尿病中胰腺α细胞对胰岛素的反应未改变。两组患者胰岛素注射后血液中的生长激素水平均无显著变化。胰岛素注射后的葡萄糖稳态并非由生长激素调节，而是主要由胰高血糖素调节。
