College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 162-1 Songdo-Dong, Yeonsu-Gu, Incheon, Republic of Korea.
Department of Pharmacy, Inha University Hospital, Incheon, Republic of Korea.
Sci Rep. 2022 Feb 7;12(1):2031. doi: 10.1038/s41598-022-06005-0.
Single-tablet regimens (STRs) should be considered for patients with HIV/AIDS to increase medication compliance and improve clinical outcomes. This study compared variations in the prescription trends between STRs and multiple-tablet regimens (MTRs) for treatment-naïve patients with HIV/AIDS after the approval of the new STRs, a proxy indicator for improvement in medication adherence. The medical and pharmacy claim data were retrospectively obtained from the Health Insurance Review and Assessment service, which contains basic information on the patients' sociodemographic characteristics and treatment information for the entire Korean population. From 2013 to 2018, a total of 6737 patients with HIV/AIDS were included. Most patients were men (92.8%, n = 6251) and insured through the National Health Insurance (95.1%, n = 6410). The mean number of pills in their antiretroviral treatment regimens decreased from 2.8 ± 1.2 in 2013 to 1.2 ± 1.0 in 2018. After the first STR (EVG/c/TDF/FTC) was approved in 2014, prescription transitions from MTR to STR were observed among more than 38% of patients. In 2018, most treatment-naïve patients were prescribed STRs (91.2%). There was a time lag for STR prescription trends in non-metropolitan hospitals compared with those in metropolitan cities. Our data provide a valuable perspective for evaluating ART regimen prescription patterns on a national scale.
单一片剂治疗方案（STR）应考虑用于 HIV/AIDS 患者，以提高药物依从性并改善临床结果。本研究比较了新 STR 获批后，治疗初治 HIV/AIDS 患者的 STR 和多片治疗方案（MTR）处方趋势的变化，这是药物依从性改善的替代指标。从 2013 年到 2018 年，共纳入了 6737 名 HIV/AIDS 患者。大多数患者为男性（92.8%，n=6251），通过国家健康保险（95.1%，n=6410）参保。他们的抗逆转录病毒治疗方案中的药丸数量从 2013 年的 2.8±1.2 减少到 2018 年的 1.2±1.0。2014 年首次批准 EVG/c/TDF/FTC 单一片剂后，观察到超过 38%的患者从 MTR 向 STR 转换。2018 年，大多数初治患者开 STR（91.2%）。与大都市医院相比，非大都市医院的 STR 处方趋势存在时间滞后。我们的数据为评估全国范围内的 ART 方案处方模式提供了有价值的视角。
