Department of Chemistry, Carleton University, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada.
Ottawa Hospital Research Institute, 1053 Carling Ave, Ottawa, ON K1Y 4E9, Canada.
Chem Commun (Camb). 2022 Feb 24;58(17):2870-2873. doi: 10.1039/d1cc03817f.
Targeting of molecular constituents of thrombi with aptamer functionalized core-shell nanoparticles (CSN) allowed for high resolution clot delineation in T2-weighted magnetic resonance imaging. Meanwhile, the gold-coating demonstrated sufficient contrast capabilities in computed tomography (1697 HU μM). This targeted CSN formulation could allow for precise imaging of blood clots at low nanomolar concentrations.
靶向血栓的分子成分与适体功能化核壳纳米粒子（CSN）结合，在 T2 加权磁共振成像中实现了高分辨率的血栓描绘。同时，金涂层在计算机断层扫描（1697 HU μM）中表现出足够的对比能力。这种靶向 CSN 制剂可以在纳摩尔浓度的低浓度下实现对血栓的精确成像。
