Epartment of urology surgery, Zhejiang hospital, Zhejiang University School of Medicine, Hangzhou, China.
School of MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Cancer Commun (Lond). 2022 Feb;42(2):88-116. doi: 10.1002/cac2.12250.
The hallmark of tumorigenesis is the successful circumvention of cell death regulation for achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell death dependent on lipid peroxidation which differs from classical programmed cell death in terms of morphology, physiology and biochemistry. The broad spectrum of injury and tumor tolerance are the main reasons for radiotherapy and chemotherapy failure. The effective rate of tumor immunotherapy as a new treatment method is less than 30%. Ferroptosis can be seen in radiotherapy, chemotherapy, and tumor immunotherapy; therefore, ferroptosis activation may be a potential strategy to overcome the drug resistance mechanism of traditional cancer treatments. In this review, the characteristics and causes of cell death by lipid peroxidation in ferroptosis are briefly described. In addition, the three metabolic regulations of ferroptosis and its crosstalk with classical signaling pathways are summarized. Collectively, these findings suggest the vital role of ferroptosis in immunotherapy based on the interaction of ferroptosis with tumor immunotherapy, chemotherapy and radiotherapy, thus, indicating the remarkable potential of ferroptosis in cancer treatment.
肿瘤发生的标志是成功规避细胞死亡调控，以实现无限复制和永生。铁死亡是一种新发现的依赖于脂质过氧化的细胞死亡类型，其在形态、生理学和生物化学方面与经典的程序性细胞死亡不同。广泛的损伤和肿瘤耐受是放疗和化疗失败的主要原因。肿瘤免疫治疗作为一种新的治疗方法的有效率低于 30%。铁死亡可发生于放疗、化疗和肿瘤免疫治疗中；因此，铁死亡的激活可能是克服传统癌症治疗药物耐药机制的一种潜在策略。在这篇综述中，简要描述了铁死亡中脂质过氧化引起的细胞死亡的特征和原因。此外，还总结了铁死亡的三种代谢调控及其与经典信号通路的串扰。总的来说，这些发现表明铁死亡在基于铁死亡与肿瘤免疫治疗、化疗和放疗相互作用的免疫治疗中起着重要作用，从而表明铁死亡在癌症治疗中有显著的潜力。
