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[尿路细胞学中的诊断和预测标志物]

[Diagnostic and predictive markers in urinary tract cytology].

作者信息

Vlajnic Tatjana, Bubendorf Lukas

机构信息

Pathologie, Institut für medizinische Genetik und Pathologie, Universitätsspital Basel, Schönbeinstr. 40, 4031, Basel, Schweiz.

出版信息

Pathologe. 2022 Mar;43(2):99-104. doi: 10.1007/s00292-022-01053-9. Epub 2022 Feb 8.

DOI:10.1007/s00292-022-01053-9
PMID:35133495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8888376/
Abstract

Multiprobe fluorescence in situ hybridization (FISH) still remains the gold standard for clarifying inconclusive atypia in urinary cytology in daily routine practice. The Paris Classification System (The Paris System, TPS) provides an important basis for the specific indication of FISH and emphasizes the importance of morphological correlation for an integrative approach to diagnosis. Next-generation sequencing technology in urinary specimens, which is highly sensitive for simultaneous detection of multiple genetic alterations, is also likely to play a diagnostic role in the near future.

摘要

多探针荧光原位杂交（FISH）在日常临床实践中仍是明确尿细胞学中不确定非典型性的金标准。巴黎分类系统（TPS）为FISH的具体应用提供了重要依据，并强调形态学关联对于综合诊断方法的重要性。尿标本中的下一代测序技术对同时检测多种基因改变具有高度敏感性，在不久的将来也可能发挥诊断作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd75/8888376/e734a69af7bc/292_2022_1053_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd75/8888376/957587978d07/292_2022_1053_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd75/8888376/bf01ca2bbc92/292_2022_1053_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd75/8888376/8bc8579f7556/292_2022_1053_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd75/8888376/e734a69af7bc/292_2022_1053_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd75/8888376/957587978d07/292_2022_1053_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd75/8888376/bf01ca2bbc92/292_2022_1053_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd75/8888376/8bc8579f7556/292_2022_1053_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd75/8888376/e734a69af7bc/292_2022_1053_Fig4_HTML.jpg

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Cytologically targeted next-generation sequencing: a synergy for diagnosing urothelial carcinoma.细胞靶向的下一代测序：诊断尿路上皮癌的协同作用。
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Assessment of Luminal and Basal Phenotypes in Bladder Cancer.膀胱癌管腔和基底表型的评估。
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