Li Yi, Yang Hong Yu, Lee Doo Sung
College of Materials and Textile Engineering, Nanotechnology Research Institute, Jiaxing University, Jiaxing, Zhejiang Province 314001, PR China.
College of Materials Science and Engineering, Jilin Institute of Chemical Technology, Jilin City 132022, PR China.
Biomacromolecules. 2022 Mar 14;23(3):609-618. doi: 10.1021/acs.biomac.1c01552. Epub 2022 Feb 8.
Injectable hydrogels are a unique class of hydrogels that are formed upon injection into living bodies. They possess features of typical hydrogels such as softness, 3D network structures, large contents of water, the ability to load water-soluble substances, and so on. Furthermore, their injectability allows injectable hydrogels to be implanted into living bodies using a syringe in a minimally invasive way. After being loaded with different active substances (drugs, proteins, genes, viruses, cells, etc.), injectable hydrogels have been demonstrated to be potential in many different biomedical applications including controlled release and tissue engineering. However, biodegradability is also an important property of injectable hydrogels and allows removal of the hydrogels after accomplishment of their tasks. In this Perspective, we aim at introducing several different types of biodegradable and injectable hydrogels and compare their differences in properties and applications. Lastly, we also point out some remaining problems and future trends in the field of biodegradable and injectable hydrogels.
可注射水凝胶是一类独特的水凝胶，在注入活体后形成。它们具有典型水凝胶的特性，如柔软性、三维网络结构、大量水分、负载水溶性物质的能力等。此外，它们的可注射性使得可注射水凝胶能够通过注射器以微创方式植入活体。在负载不同的活性物质（药物、蛋白质、基因、病毒、细胞等）后，可注射水凝胶已被证明在许多不同的生物医学应用中具有潜力，包括控释和组织工程。然而，生物可降解性也是可注射水凝胶的一个重要特性，使得水凝胶在完成任务后能够被去除。在这篇综述中，我们旨在介绍几种不同类型的可生物降解且可注射的水凝胶，并比较它们在性质和应用方面的差异。最后，我们还指出了可生物降解且可注射水凝胶领域中一些尚存的问题和未来趋势。
