Vadivel Dhanalakshmi, Zitarosa Nicolò, Dondi Daniele
Department of Chemistry, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy.
INFN, Sezione di Pavia, Via Agostino Bassi 6, 27100, Pavia, Italy.
Heliyon. 2023 Jun 5;9(6):e16850. doi: 10.1016/j.heliyon.2023.e16850. eCollection 2023 Jun.
The use of 3D printing began to diffuse in the pharmaceutical field in recent times, since 2015, with the approval of the first 3D printed drug from the FDA. The most used materials in association with this technique in this specific scope are hydrogels, already used widely in tissue engineering to produce scaffolds used in the realization of synthetic tissues. The aim of this project was to study the influence of different pH conditions on the release of a therapeutic molecule from a Carrageenan-k combined with alginate or xanthan gum hydrogel with a high level of biocompatibility and enough mechanical resistance to be used as printing material for a 3D bioprinter. The addition of biologically active supplements without affecting the model of the 3D printing structure of the biocompatible polymers was achieved by adopting the extrusion at moderately low temperatures. This study aimed to produce the necessary percentage of hydrogels which is responsible for the release of active drugs which respect to the pH of the system. In this case, the chosen curcumin drug which exhibits active release in the pH of the small intestine is a pH value of 6.
自2015年美国食品药品监督管理局（FDA）批准首款3D打印药物以来，3D打印技术最近开始在制药领域得到推广。在这一特定领域中，与该技术结合使用最多的材料是水凝胶，水凝胶在组织工程中已被广泛用于生产用于合成组织的支架。本项目的目的是研究不同pH条件对治疗性分子从卡拉胶 - k与具有高生物相容性和足够机械抗性的藻酸盐或黄原胶组合水凝胶中释放的影响，这种水凝胶可作为3D生物打印机的打印材料。通过在适度低温下采用挤出法，在不影响生物相容性聚合物3D打印结构模型的情况下添加生物活性补充剂。本研究旨在制备出必要比例的水凝胶，该水凝胶负责在特定系统pH值下释放活性药物。在这种情况下，所选的姜黄素药物在小肠pH值下表现出活性释放，该pH值为6。
