College of Materials and Textile Engineering, Jiaxing University, Jiaxing 314001, Zhejiang, PR China; Nanotechnology Research Institute (NRI), Jiaxing University, Jiaxing 314001, Zhejiang, PR China.
College of Materials Science and Engineering, Jilin Institute of Chemical Technology, Jilin City 132022, PR China.
J Control Release. 2021 Feb 10;330:151-160. doi: 10.1016/j.jconrel.2020.12.008. Epub 2020 Dec 10.
In situ-forming injectable hydrogels are smart biomaterials that can be implanted into living bodies with minimal invasion. Due to pioneer work of Prof. Sung Wan Kim in this field, injectable hydrogels have shown great potentials in many different biomedical applications. Biodegradable and injectable hydrogels can be administered at room temperature as viscous polymer sols. They will degrade after accomplishing their tasks. Before injecting into living bodies, active substances can be loaded into viscous polymer sols with a high loading efficiency by simple mixing. After injecting into living bodies, active substances-loaded hydrogels can be formed and active substances can be released in a controlled manner upon diffusion or polymer degradation. Due to their outstanding properties and unique features, injectable hydrogels are very promising in many biomedical applications including drug/protein/gene delivery, tissue engineering, and regenerative medicine. In this review, we briefly introduce recent development of several important types of in situ-forming injectable hydrogels reported by our group during the last three years. Important properties and potential applications (such as cancer therapy, insulin release and wound healing) of these injectable hydrogels are reviewed. Challenges and perspectives in this research field are also discussed.
原位形成可注射水凝胶是一种智能生物材料，可以微创植入体内。由于 Sung Wan Kim 教授在该领域的开创性工作，可注射水凝胶在许多不同的生物医学应用中显示出巨大的潜力。可生物降解和可注射的水凝胶可以在室温下作为粘性聚合物溶胶给药。它们在完成任务后会降解。在注入体内之前，可以通过简单的混合将活性物质以高载药效率载入粘性聚合物溶胶中。注入体内后，可形成载药水凝胶，活性物质可通过扩散或聚合物降解以受控方式释放。由于其出色的性能和独特的特点，可注射水凝胶在许多生物医学应用中非常有前途，包括药物/蛋白质/基因传递、组织工程和再生医学。在这篇综述中，我们简要介绍了我们小组在过去三年中报道的几种重要类型的原位形成可注射水凝胶的最新进展。综述了这些可注射水凝胶的重要性质和潜在应用（如癌症治疗、胰岛素释放和伤口愈合）。还讨论了该研究领域的挑战和展望。
