Department of Microbiology, Faculty of Medicine, University of Peradeniya, Kandy, Sri Lanka.
Teaching Hospital, Peradeniya, Sri Lanka.
PLoS One. 2022 Feb 8;17(2):e0263167. doi: 10.1371/journal.pone.0263167. eCollection 2022.
Prescribers have a major role in preventing antimicrobial resistance (AMR) through appropriate prescribing. However, in countries like Sri Lanka, where continuous professional development is not mandatory for license renewal and antimicrobial stewardship is not implemented, prescribing practices go largely unchecked.
To identify the knowledge on antibiotic use and practices related to antibiotic prescribing among Sri Lankan doctors.
This cross-sectional study was conducted in 2020. We used a validated, pretested Google-form based questionnaire with multiple choices, single best answer questions, polar questions (Yes/No) and five-point Likert scale questions. The Google-sheet generated was used for data analysis. Knowledge and practice scores were calculated.
Of the 262 respondents, 40.1% were males. Majority (61.8%) were aged 25-35-years and in medical practice for 0-5 years (48.9%) while 46.2% had or were engaged in post graduate studies. Knowledge scores ranged from 98.31% to 46.55% [mean:71.27% (SD±10.83); median:71.18% (IQR 64.4-79.7)]. Most (98.09%) obtained ≥50 marks while 45.8% scored more than the mean. The practice scores ranged from 100% to 0% [mean:65.33% (SD±18.16), median:66.67% (IQR53.3-80)]. The majority (81.3%) scored ≥50 in the practice score while 52.3% achieved more than the mean practice score. The knowledge score and the practice score differed significantly (p<0.001, related sample Wilcoxon Signed Rank Test) but the knowledge and practice scores were significantly correlated [Spearman correlation, p<0.001, r = 0.343 (Bias corrected 95% CI 0.237-0.448)]. Knowledge scores and the practice scores were significantly higher in those with or undergoing postgraduate training.
While the knowledge and practice scores were high, and knowledge and practice scores were correlated, the practices score was lower than that of knowledge indicating the need to encourage correct practices through means other than solely promoting knowledge.
通过合理用药，处方医生在预防抗生素耐药性（AMR）方面发挥着重要作用。然而，在斯里兰卡等国家，连续专业发展并非执照续期的强制性要求，也未实施抗菌药物管理，因此处方行为在很大程度上未受到监管。
了解斯里兰卡医生对抗生素使用的认知和与抗生素处方相关的实践情况。
本横断面研究于 2020 年进行。我们使用了一份经过验证的、预测试的基于 Google 表单的问卷，其中包含多项选择、单项最佳答案、极性问题（是/否）和五分制李克特量表问题。Google 表生成的数据用于分析。我们计算了知识和实践得分。
在 262 名受访者中，40.1%为男性。大多数（61.8%）年龄在 25-35 岁之间，医疗实践经验为 0-5 年（48.9%），而 46.2%的人已经或正在接受研究生教育。知识得分范围为 98.31%至 46.55%[平均值：71.27%（标准差±10.83%）；中位数：71.18%（四分位距 64.4-79.7）]。大多数（98.09%）获得了≥50 分，而 45.8%的得分高于平均值。实践得分范围为 100%至 0%[平均值：65.33%（标准差±18.16%），中位数：66.67%（四分位距 53.3-80）]。大多数（81.3%）在实践得分中获得了≥50 分，而 52.3%的人获得了高于平均值的实践得分。知识得分和实践得分有显著差异（p<0.001，相关样本 Wilcoxon 符号秩检验），但知识得分和实践得分呈显著相关[Spearman 相关，p<0.001，r=0.343（校正后的偏倚 95%置信区间 0.237-0.448）]。有或正在接受研究生培训的人的知识得分和实践得分较高。
尽管知识和实践得分都很高，且知识得分和实践得分呈正相关，但实践得分低于知识得分，这表明需要通过除提高知识以外的其他方法来鼓励正确的实践。
