Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
Flinders University - College of Medicine and Public Health, Adelaide, South Australia, Australia.
PLoS One. 2022 Feb 8;17(2):e0263744. doi: 10.1371/journal.pone.0263744. eCollection 2022.
Studies assessing normative values and sex differences in pulmonary function test parameters (PFTPs) among Indigenous populations are sparse.
PFTPs were compared between male and female Indigenous Australian adults with and without chest radiologically proven chronic airway diseases (CADs).
485 adults (56% were female) with no significant difference in age, body mass index or smoking status between sexes were included. Females displayed a higher prevalence of radiology without CADs compared to males (66 vs. 52%, respectively). Among patients without CADs, after adjustment for age, stature and smoking, males displayed significantly higher absolute values of Forced Vital Capacity (FVC) (mean difference, 0.41L (0.21,0.62), p<0.001) and Forced Expiratory Volume in one second (FEV1) (mean difference 0.27L (0.07,0.47), p<0.001), with no significant difference in FEV1/FVC ratio (mean difference -0.02 (-0.06, 0.02), p = 0.174). Male and female patients with radiologically proven CADs demonstrated lower FEV1/FVC values. However, compared to females, males showed significantly greater reductions in pre- [-0.53 (-0.74, -0.32) vs. -0.29 (-0.42, -0.16), p = 0.045] and post- [-0.51 (-0.72, -0.3) vs. -0.27 (-0.39, -0.14), p = 0.049] bronchodilator FEV1.
There are significant sex differences in the PFTPs among Indigenous Australians. Recognising these differences may be of value in the accurate diagnosis, management, monitoring and prognostication of CADs in this population.
评估原住民人群肺功能测试参数（PFTPs）的正常值和性别差异的研究很少。
比较了有和没有胸部放射学证实的慢性气道疾病（CADs）的澳大利亚原住民成年男性和女性的 PFTPs。
纳入了 485 名成年人（56%为女性），男女之间的年龄、体重指数或吸烟状况无显著差异。与男性相比，女性患有无 CAD 的放射学表现更为普遍（分别为 66%和 52%）。在没有 CAD 的患者中，调整年龄、身高和吸烟因素后，男性的用力肺活量（FVC）绝对值明显更高（平均差异，0.41L（0.21，0.62），p<0.001）和一秒用力呼气量（FEV1）（平均差异 0.27L（0.07，0.47），p<0.001），FEV1/FVC 比值无显著差异（平均差异 -0.02（-0.06，0.02），p = 0.174）。有放射学证实 CAD 的男性和女性患者的 FEV1/FVC 值较低。然而，与女性相比，男性在预 [-0.53（-0.74，-0.32）对-0.29（-0.42，-0.16），p = 0.045]和后 [-0.51（-0.72，-0.3）对-0.27（-0.39，-0.14），p = 0.049]支气管扩张剂 FEV1 方面的下降更为显著。
澳大利亚原住民的 PFTPs 存在显著的性别差异。在该人群中，认识到这些差异可能对 CAD 的准确诊断、管理、监测和预后具有重要价值。
