Discipline of Orthodontics and Paediatric Dentistry Sydney Dental School, Faculty of Medicine and Health, University of Sydney, Sydney Dental Hospital, Sydney Local Health District, Surry Hills, NSW, Australia.
Eur J Orthod. 2022 Aug 16;44(4):427-435. doi: 10.1093/ejo/cjab079.
To evaluate the effects of minimally invasive micro-osteoperforations (MOPs) on orthodontic tooth movement and pain.
Prospective, split-mouth, randomized controlled trial.
Single-centre, university hospital.
Twenty subjects requiring maxillary first premolar extractions were included. Right and left sides of the maxilla were randomly allocated into experimental and controls. Space closure was initiated following alignment on 0.20″ stainless steel archwires, using 150 g force, applied by coil springs on power arms. Nance-TPA was used for anchorage. On the experimental side, two 5 mm deep MOPs in vertical alignment on distal aspect of the maxillary canine mid-root region were performed prior to space closure.
The primary outcome was the amount of tooth movement during space closure, measured every 4 weeks for 12 weeks (T1, T2, and T3). Secondary outcome was the pain levels related to MOP, measured using Visual Analogue Scale (VAS) questionnaires. Significance was set at P < 0.01.
Randomization was generated using a randomization table, and allocation was concealed in sequentially numbered, opaque, sealed envelopes.
Blinding was not possible during the experiment but assessor was blinded during outcome assessment.
All subjects completed the study, with tooth movement measurements available for all 20 patients for T0-T2. In three patients, space was closed on one side at T2. The average tooth movement between sides at three intervals (T0-T1, T1-T2, and T2-T3) were not significantly different. Overall difference following 12 weeks (T0-T3) was 0.69 mm higher on the experimental side (P < 0.001). No harms were observed.
Short-term study, cast measurements done with digital callipers.
This 12-week randomized split-mouth controlled clinical trial showed two MOPs that are 5 mm deep, applied once prior to space closure, did not create clinically significant increase in maxillary premolar space closure.
The protocol was not published before trial commencement.
Trial was not registered.
The Australian Society of Orthodontists Foundation for Research and Education.
评估微创微骨穿孔（MOPs）对正畸牙齿移动和疼痛的影响。
前瞻性、分口、随机对照试验。
单中心、大学医院。
纳入 20 名需要上颌第一前磨牙拔牙的患者。上颌的右侧和左侧随机分配到实验组和对照组。在 0.20 英寸不锈钢弓丝上对齐后，使用 150g 力，通过螺旋弹簧施加于动力臂上开始关闭间隙。Nance-TPA 用于锚固。在实验组，在尖牙中根区远中面垂直排列进行两个 5 毫米深的 MOPs 后，开始关闭间隙。
主要结果是关闭间隙期间牙齿移动的量，每 4 周测量一次，共 12 周（T1、T2 和 T3）。次要结果是与 MOP 相关的疼痛程度，使用视觉模拟量表（VAS）问卷进行测量。显著性设定为 P < 0.01。
使用随机数表生成随机化，并用顺序编号、不透明、密封的信封隐藏分配。
实验过程中无法进行盲法，但在结果评估时评估者是盲法的。
所有患者均完成了研究，20 名患者的所有患者均有 T0-T2 的牙齿移动测量值。在 3 名患者中，T2 时一侧的间隙已经关闭。在三个时间间隔（T0-T1、T1-T2 和 T2-T3）之间两侧的平均牙齿移动没有显著差异。12 周（T0-T3）后总体差异为实验组高 0.69 毫米（P < 0.001）。未观察到任何伤害。
短期研究，使用数字卡尺进行铸型测量。
这项为期 12 周的随机分口对照临床试验表明，两次 5 毫米深的 MOPs 在关闭间隙前应用一次，不会导致上颌前磨牙间隙关闭出现临床显著增加。
在试验开始前，方案未发表。
试验未注册。
澳大利亚正畸学会研究和教育基金会。
