Department of Pediatric Infectious Diseases and Immunology, Amalia Children's Hospital, Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Laboratory of Medical Immunology, Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Clin Infect Dis. 2022 Sep 10;75(4):719-722. doi: 10.1093/cid/ciac079.
The Streptococcus pneumoniae capsule is regarded as indispensable in bacteremia. We report an infant with a ventricular septal defect and infective endocarditis caused by nontypeable S. pneumoniae. In-depth investigation confirmed a deficient capsule yet favored pneumococcal fitness for causing infective endocarditis, rather than a host immune disorder, as the cause of infective endocarditis in this case.
肺炎链球菌荚膜被认为在菌血症中不可或缺。我们报告了一例由非典型肺炎链球菌引起的伴有室间隔缺损和感染性心内膜炎的婴儿。深入调查证实了荚膜的缺乏,但支持了肺炎链球菌引起感染性心内膜炎的适应能力,而不是宿主免疫紊乱,是导致该病例感染性心内膜炎的原因。