College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, PR China; Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, PR China.
Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, PR China.
J Ethnopharmacol. 2022 May 23;290:115075. doi: 10.1016/j.jep.2022.115075. Epub 2022 Feb 5.
Slow transit constipation (STC) is a common gastrointestinal disorder seriously impacting patients' quality of life. At present, although conventional chemical drugs effectively control STC symptoms in the short term, the long-term effects are poor, and the side effects are significant. In this regard, traditional Chinese medicine (TCM) offers an opportunity for STC treatment. Many pharmacological and clinical studies have confirmed this efficacy of TCM with multiple targets and mechanisms.
This review attempted to summarize the characteristics of TCM (compound prescriptions, single Chinese herbs, and active ingredients) for STC treatment and discussed their efficacy based on analyzing the pathogenesis of STC.
The information was acquired from different databases, including PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang databases. We then focused on the recent research progress in STC treatment by TCM. Finally, the future challenges and trends are proposed.
TCM has good clinical efficacy in the treatment of STC with multi-mechanisms. Based on the theory of syndrome differentiation, five kinds of dialectical treatment for STC by compound TCM prescriptions were introduced, namely: Nourishing Yin and moistening the intestines; Promoting blood circulation and removing blood stasis; Warming Yang and benefiting Qi; Soothing the liver and regulating Qi; and Benefiting Qi and strengthening the spleen. In addition, six single Chinese herbs and eight active ingredients also show good efficacy in STC treatment.
TCM, especially compound prescriptions, has bright prospects in treating STC attributed to its various holistic effects.
慢传输型便秘（STC）是一种常见的胃肠道疾病，严重影响患者的生活质量。目前，虽然常规化学药物能在短期内有效控制 STC 症状，但长期效果不佳，且副作用明显。在这方面，中药（TCM）为 STC 治疗提供了机会。许多药理学和临床研究证实了 TCM 具有多靶点和多机制的疗效。
本综述试图总结 TCM（复方方剂、单味中药和活性成分）治疗 STC 的特点，并通过分析 STC 的发病机制来讨论其疗效。
从不同的数据库（包括 PubMed、Web of Science、中国国家知识基础设施和万方数据库）获取信息。然后，我们专注于 TCM 治疗 STC 的最新研究进展。最后，提出了未来的挑战和趋势。
TCM 以多机制治疗 STC 具有良好的临床疗效。基于辨证论治理论，介绍了复方 TCM 方剂治疗 STC 的五种辨证治疗方法，即滋阴润肠、活血化瘀、温阳益气、疏肝理气、益气健脾。此外，六种单味中药和八种活性成分在治疗 STC 方面也显示出良好的疗效。
TCM，特别是复方方剂，在治疗 STC 方面具有广阔的前景，因为它具有多种整体作用。
