Chen Peng, Zhang Jie, Wang Chen, Chai Yi-Hui, Wu An-Guo, Huang Ning-Yu, Wang Long
Basic Medical School, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China; Accreditation Center of Traditional Chinese Medicine Physician, National Administration of Traditional Chinese Medicine, Beijing, China.
Basic Medical School, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Phytomedicine. 2022 Jun;100:154044. doi: 10.1016/j.phymed.2022.154044. Epub 2022 Mar 15.
Parkinson's disease (PD) is the second most common neurodegenerative disease with no treatment currently available to modify its progression. Traditional Chinese medicine (TCM) has gained attention for its unique theoretical basis and clinical effects. Many studies have reported on the clinical effects and pharmacological mechanisms of Chinese herbs in PD. However, few studies have focused on the treatment mechanisms of anti-PD TCM drugs from the perspective of TCM itself.
To elaborate the treatment mechanisms of anti-PD TCM drugs in the perspective of TCM.
We performed a literature survey using traditional books of Chinese medicine and online scientific databases including PubMed, Web of Science, Google Scholar, China National Knowledge Infrastructure (CNKI), and others up to July 2021.
TCM theory states that PD is caused by a dysfunction of the zang-fu organs (liver, spleen, kidney, and lung) and subsequent pathogenic factors (wind, fire, phlegm, and blood stasis). Based on the pathogenesis, removing pathogenic factors and restoring visceral function are two primary treatment principles for PD in TCM. The former includes dispelling wind, clearing heat, resolving phlegm, and promoting blood circulation, while the latter involves nourishing the liver and kidney and strengthening the spleen. The anti-PD mechanisms of the active ingredients of TCM compounds and herbs at different levels include anti-apoptosis, anti-inflammation, and anti-oxidative stress, as well as the restoration of mitochondrial function and the regulation of autophagy and neurotransmitters.
Chinese herbs and prescriptions can be used to treat PD by targeting multiple pharmacological mechanisms.
帕金森病（PD）是第二常见的神经退行性疾病，目前尚无能够改变其病程的治疗方法。传统中医（TCM）因其独特的理论基础和临床疗效而受到关注。许多研究报道了中药在帕金森病中的临床疗效和药理机制。然而，从中医自身角度关注抗帕金森病中药治疗机制的研究较少。
从中医角度阐述抗帕金森病中药的治疗机制。
我们使用中医经典书籍以及包括PubMed、科学网、谷歌学术、中国知网等在内的在线科学数据库进行文献检索，检索截至2021年7月。
中医理论认为，帕金森病是由脏腑（肝、脾、肾、肺）功能失调及后续致病因素（风、火、痰、血瘀）所致。基于发病机制，祛邪和恢复脏腑功能是中医治疗帕金森病的两大主要原则。前者包括祛风、清热、化痰、活血化瘀，后者包括滋补肝肾和健脾。中药复方及单味药活性成分在不同层面的抗帕金森病机制包括抗凋亡、抗炎、抗氧化应激，以及恢复线粒体功能和调节自噬与神经递质。
中药及其方剂可通过靶向多种药理机制来治疗帕金森病。
