Fatih Sultan Mehmet Training and Research Hospital, Departmant of Ophtalmolgy, Istanbul, Turkey.
Fatih Sultan Mehmet Training and Research Hospital, Departmant of Ophtalmolgy, Istanbul, Turkey.
Photodiagnosis Photodyn Ther. 2022 Jun;38:102751. doi: 10.1016/j.pdpdt.2022.102751. Epub 2022 Feb 6.
To evaluate the retinal vascular caliber using fundus photography in patients with newly diagnosed iron deficiency anemia (IDA).
This study included 56 eyes of 28 female patients with IDA and the 56 eyes of 28 age- and sex-matched healthy participants. Retinal vascular calibers were measured using image analysis software from fundus photographs. The central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE) and arteriole-to-venule ratio (AVR) were compared between groups. Linear regression analysis was used to quantify the relative impact of hemoglobin level on CRAE, CRVE, and AVR.
The CRAE was significantly narrower in patients with IDA. However, no such difference appeared between groups in CRVE. AVR was significantly lower among patients with IDA than in the control group. Linear regression analysis revealed that in patients with IDA, hemoglobin level was associated with CRAE and CRVE but not with AVR. Among non-anemic individuals, there was also no association between hemoglobin level and CRAE, CRVE, or AVR.
Our results showing that the CRAE is significantly narrower in patients with IDA than in healthy non-anemic individuals suggests that vascular caliber may reflect early microvascular alterations resulting from IDA. Added to that, hemoglobin level was associated with CRAE and CRVE in our linear regression analysis of patients with IDA. Certain changes in retinal vascular caliber are also clearly associated with high blood pressure, cardiovascular risk, and mortality. It may be critical to identify all alterations in retinal vascular caliber in order to prevent potential ocular and systemic disorders in patients with IDA.
评估眼底摄影在新诊断的缺铁性贫血（IDA）患者中的视网膜血管口径。
本研究纳入了 28 名女性 IDA 患者的 56 只眼和 28 名年龄、性别匹配的健康对照者的 56 只眼。使用眼底照相图像分析软件测量视网膜血管口径。比较两组间中央视网膜动脉等效直径（CRAE）、中央视网膜静脉等效直径（CRVE）和动静脉比（AVR）。采用线性回归分析量化血红蛋白水平对 CRAE、CRVE 和 AVR 的相对影响。
IDA 患者的 CRAE 明显变窄。然而，两组间 CRVE 无差异。IDA 患者的 AVR 明显低于对照组。线性回归分析显示，IDA 患者的血红蛋白水平与 CRAE 和 CRVE 相关，但与 AVR 无关。在非贫血个体中，血红蛋白水平与 CRAE、CRVE 或 AVR 也无相关性。
我们的结果显示，IDA 患者的 CRAE 明显窄于健康非贫血个体，这表明血管口径可能反映了 IDA 引起的早期微血管改变。此外，我们对 IDA 患者进行的线性回归分析显示，血红蛋白水平与 CRAE 和 CRVE 相关。视网膜血管口径的某些变化也与高血压、心血管风险和死亡率明显相关。识别 IDA 患者视网膜血管口径的所有改变可能至关重要，以预防潜在的眼部和全身疾病。
