Malyutina S K, Direev A O, Munz I V, Palekhina Yu Yu, Ryabikov A N
Novosibirsk State Medical University, Novosibirsk, Russia.
Federal Research Center Institute of Cytology and Genetics - Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Vestn Oftalmol. 2022;138(5):14-21. doi: 10.17116/oftalma202213805114.
In an aging society, age-dependent diseases with high mortality, including cardiovascular diseases (CVD) and type 2 diabetes mellitus (DM2), occupy a special place. There is only limited population-based data on the relationship between cardiometabolic diseases and target-organ damage, including ocular microvasculature.
To explore the associations between the caliber of retinal vessels and cardiometabolic diseases in a population sample of men and women from middle-aged to elderly (Novosibirsk).
The subjects were participants of the Russian cohort - part of the international project HAPIEE, and were initially examined in 2003-2005 (=9360, aged 45-69 years, Novosibirsk). At the third survey in 2015-2017, a random sub-sample of men and women (=1011) was formed for an in-depth evaluation. We performed a calibrometric analysis involving measurement of central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), and CRAE-to-CRVE ratio (AVR).
In a population sample of men and women aged 55-84 years, age increment is accompanied by a decrease in the calibers of retinal arterioles and venules (<0.001). Arterial hypertension (AH) was accompanied by a decrease in CRAE, CRVE (=0.001) and AVR (<0.001); the associations between AH, CRAE and AVR were independent from other factors. Multivariate analysis showed that CRAE and CRVE were inversely associated with the presence of DM2 (=0.026). Carotid atherosclerosis was accompanied by an increase in CRVE (<0.002); this relationship was mainly attributed to age and metabolic factors. There were no associations between carotid atherosclerosis and either CRAE or AVR. The multivariate analysis identified the weak positive associations of CRAE and AVR with the presence of ischemic heart disease and CVD.
In the examined population sample aged 55-84 years, a number of associations were detected between retinal vascular caliber and cardiometabolic diseases. The observed changes in the microvascular bed of the retina may be important for prognosis of the course of common cardiometabolic diseases.
在老龄化社会中，包括心血管疾病（CVD）和2型糖尿病（DM2）在内的高死亡率的年龄相关性疾病占据特殊地位。关于心脏代谢疾病与靶器官损害（包括眼部微血管）之间关系的基于人群的数据有限。
在一个从中年到老年的男性和女性人群样本（新西伯利亚）中探索视网膜血管管径与心脏代谢疾病之间的关联。
研究对象是俄罗斯队列的参与者——国际项目HAPIEE的一部分，于2003 - 2005年首次接受检查（=9360人，年龄45 - 69岁，新西伯利亚）。在2015 - 2017年的第三次调查中，形成了一个男性和女性的随机子样本（=1011人）用于深入评估。我们进行了校准分析，包括测量视网膜中央动脉等效直径（CRAE）、视网膜中央静脉等效直径（CRVE）以及CRAE与CRVE的比值（AVR）。
在年龄为55 - 84岁的男性和女性人群样本中，年龄增长伴随着视网膜小动脉和小静脉管径减小（<0.001）。动脉高血压（AH）伴随着CRAE、CRVE减小（=0.001）以及AVR减小（<0.001）；AH、CRAE和AVR之间的关联独立于其他因素。多变量分析表明，CRAE和CRVE与DM2的存在呈负相关（=0.026）。颈动脉粥样硬化伴随着CRVE增加（<0.002）；这种关系主要归因于年龄和代谢因素。颈动脉粥样硬化与CRAE或AVR之间均无关联。多变量分析确定了CRAE和AVR与缺血性心脏病和CVD的存在呈弱正相关。
在年龄为55 - 84岁的受检人群样本中，检测到视网膜血管管径与心脏代谢疾病之间存在多种关联。视网膜微血管床中观察到的变化可能对常见心脏代谢疾病病程的预后具有重要意义。
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